奥美拉唑治疗或萎缩性胃炎所致胃酸缺乏对蛋白结合型维生素B12吸收的影响。
Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption.
作者信息
Saltzman J R, Kemp J A, Golner B B, Pedrosa M C, Dallal G E, Russell R M
机构信息
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
出版信息
J Am Coll Nutr. 1994 Dec;13(6):584-91. doi: 10.1080/07315724.1994.10718452.
OBJECTIVE
To investigate the effects of hypochlorhydria and acidic drink ingestion on protein-bound vitamin B12 absorption in elderly subjects.
METHODS
Absorption of protein-bound vitamin B12 was examined in elderly normal subjects (n = 8), and in hypochlorhydric subjects due to omeprazole treatment (n = 8) or with atrophic gastritis (n = 3). Subjects underwent absorption tests of protein-bound vitamin B12 ingested with water, cranberry juice and 0.1 N hydrochloric acid.
RESULTS
Protein-bound vitamin B12 absorption was lower in the omeprazole-treated group (0.50%) compared to the normal group (1.21%; p < 0.001). With cranberry juice ingestion, the omeprazole-treated group showed an increase in absorbed protein-bound vitamin B12 (p = 0.025). With dilute hydrochloric acid ingestion, there was a further increase in vitamin B12 absorption (p < 0.001).
CONCLUSION
Omeprazole causes protein-bound vitamin B12 malabsorption, and ingestion of an acidic drink improves protein-bound vitamin B12 absorption.
目的
研究胃酸过少及摄入酸性饮品对老年受试者中与蛋白质结合的维生素B12吸收的影响。
方法
对老年正常受试者（n = 8）、因奥美拉唑治疗导致胃酸过少的受试者（n = 8）或患有萎缩性胃炎的受试者（n = 3）进行与蛋白质结合的维生素B12吸收情况检查。受试者接受了与水、蔓越莓汁和0.1N盐酸一同摄入的与蛋白质结合的维生素B12的吸收测试。
结果
与正常组（1.21%；p < 0.001）相比，奥美拉唑治疗组中与蛋白质结合的维生素B12吸收较低（0.50%）。摄入蔓越莓汁后，奥美拉唑治疗组中吸收的与蛋白质结合的维生素B12有所增加（p = 0.025）。摄入稀盐酸后，维生素B12吸收进一步增加（p < 0.001）。
结论
奥美拉唑导致与蛋白质结合的维生素B12吸收不良，摄入酸性饮品可改善与蛋白质结合的维生素B12的吸收。
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