Zeitz P S, Butler J C, Cheek J E, Samuel M C, Childs J E, Shands L A, Turner R E, Voorhees R E, Sarisky J, Rollin P E
Division of Field Epidemiology, Centers for Disease Control and Prevention, Atlanta, Georgia.
J Infect Dis. 1995 Apr;171(4):864-70. doi: 10.1093/infdis/171.4.864.
In May 1993, an outbreak of hantavirus pulmonary syndrome (HPS) occurred in the southwestern United States. A case-control study determined risk factors for HPS. Seventeen case-patients were compared with 3 groups of controls: members of case-patient households (household controls), members of neighboring households (near controls), and members of randomly selected households > or = 24 km away (far controls). Investigators trapped more small rodents at case households than at near (P = .03) or far control households (P = .02). After the number of small rodents was controlled for, case-patients were more likely than household controls to hand plow (odds ratio [OR], 12.3; 95% confidence interval [CI], 1.1-143.0) or to clean feed storage areas (OR, 33.4; 95% CI, 1.7-666.0). Case-patients were more likely than near controls to plant (OR, 6.2; 95% CI, 1.1-34.0) and more likely than far controls to clean animal sheds (OR, 11.9; 95% CI, 1.4-103.0). Peridomestic cleaning, agricultural activities, and an increased number of small rodents at the household were associated with HPS.
1993年5月，美国西南部爆发了汉坦病毒肺综合征（HPS）。一项病例对照研究确定了HPS的危险因素。将17例病例患者与3组对照进行比较：病例患者家庭的成员（家庭对照）、相邻家庭的成员（近对照）以及随机选择的距离≥24公里的家庭的成员（远对照）。研究人员在病例家庭捕获的小型啮齿动物比在近对照家庭（P = 0.03）或远对照家庭（P = 0.02）更多。在对小型啮齿动物数量进行控制后，病例患者比家庭对照更有可能进行手耕（比值比[OR]，12.3；95%置信区间[CI]，1.1 - 143.0）或清理饲料储存区域（OR，33.4；95% CI，1.7 - 666.0）。病例患者比近对照更有可能进行种植（OR，6.2；95% CI，1.1 - 34.0），比远对照更有可能清理畜棚（OR，11.9；95% CI，1.4 - 103.0）。家庭周围的清洁、农业活动以及家庭中增多的小型啮齿动物与HPS有关。
