Stewart J R, Fajardo L F, Gillette S M, Constine L S
Division of Radiation Oncology, University of Utah Medical Center, Salt Lake City, USA.
Int J Radiat Oncol Biol Phys. 1995 Mar 30;31(5):1205-11. doi: 10.1016/0360-3016(94)00656-6.
For the RTOG Consensus Conference on Late Effects of Cancer Treatment we summarize the clinical manifestations of cardiac complications appearing months to years following incidental irradiation of the heart during treatment of thoracic neoplasms. The most common effects present as pericardial disease, however, it is becoming more clear that precocious or accelerated coronary artery disease is an important late effect, especially in patients treated with radiation before the age of 21 years. To the extent it is known, the pathophysiology of the various syndromes is described and the extensive literature on dose, volume, and fractionation factors is reviewed. Based upon our current understanding of late cardiac effects, a clinical grading system has been developed and is published elsewhere in this issue.
在放射治疗肿瘤学组（RTOG）关于癌症治疗晚期效应的共识会议上，我们总结了在胸部肿瘤治疗期间心脏受到意外照射后数月至数年出现的心脏并发症的临床表现。最常见的效应表现为心包疾病，然而，早熟或加速的冠状动脉疾病作为一种重要的晚期效应正变得越来越清晰，尤其是在21岁之前接受放疗的患者中。就目前所知，描述了各种综合征的病理生理学，并回顾了关于剂量、体积和分割因素的大量文献。基于我们目前对心脏晚期效应的理解，已制定了一种临床分级系统，并在本期其他地方发表。
