van Elburg R M, Uil J J, Kokke F T, Mulder A M, van de Broek W G, Mulder C J, Heymans H S
Department of Pediatrics, Beatrix Children's Hospital, University Hospital of Groningen, The Netherlands.
J Pediatr Gastroenterol Nutr. 1995 Feb;20(2):184-8. doi: 10.1097/00005176-199502000-00008.
Differential sugar-absorption tests for measuring intestinal permeability for sugars have been studied in a variety of gastrointestinal diseases. Their use in general practice has been hampered by a lack of data on reference values and repeatability of the test and the laboratory assay. In this study, we determined the reference values of the sugar-absorption test, using lactulose and mannitol as probe molecules, for children and adults. The repeatability of the test is good; linear relationship: slope, 0.825 [95% confidence interval (CI), 0.571, 1.152); intercept, 0.005 (95% CI, -0.004, 0.010). The repeatability of the laboratory assay for the sugar-absorption test is excellent; linear relationship: slope, 1.014 (95% CI, 0.870, 1.094); intercept, 0.002 (95% CI, -0.005, 0.010). The validation of the sugar-absorption test makes the test useful as a simple, noninvasive, reliable intestinal permeability test for sugars, which can be of use for clinical practice. Taking possible interfering factors into account, the sugar-absorption test can be used as a diagnostic test for enteropathy of different etiologies and evaluation of therapeutic interventions in both children and adults. Studies with the sugar-absorption test may clarify the role of intestinal permeability in the pathophysiology of a variety of gastrointestinal diseases.
用于测量糖类肠道通透性的差异糖吸收试验已在多种胃肠道疾病中得到研究。由于缺乏关于参考值、试验重复性以及实验室检测的相关数据，其在一般临床实践中的应用受到了阻碍。在本研究中，我们以乳果糖和甘露醇作为探针分子，确定了儿童和成人糖吸收试验的参考值。该试验的重复性良好；线性关系：斜率为0.825 [95%置信区间（CI），0.571，1.152]；截距为0.005（95% CI，-0.004，0.010）。糖吸收试验的实验室检测重复性极佳；线性关系：斜率为1.014（95% CI，0.870，1.094）；截距为0.002（95% CI，-0.005，0.010）。糖吸收试验的验证使得该试验成为一种简单、无创、可靠的糖类肠道通透性检测方法，可用于临床实践。考虑到可能的干扰因素，糖吸收试验可作为不同病因肠病的诊断试验以及儿童和成人治疗干预效果的评估方法。糖吸收试验的研究可能会阐明肠道通透性在多种胃肠道疾病病理生理学中的作用。
