一种在嗅觉感觉神经元中特异性表达的受体鸟苷酸环化酶。

Fülle H J, Vassar R, Foster D C, Yang R B, Axel R, Garbers D L

Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235-9050, USA.

Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3571-5. doi: 10.1073/pnas.92.8.3571.

We have cloned an additional member (GC-D) of the membrane receptor guanylyl cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] family that is specifically expressed in a subpopulation of olfactory sensory neurons. The extracellular, putative ligand-binding domain of the olfactory cyclase is similar in primary structure to two guanylyl cyclases expressed in the retina but diverges considerably from other known guanylyl cyclases. The expression of GC-D RNA is restricted to a small, randomly dispersed population of neurons that is within a single topographic zone in the olfactory neuroepithelium and resembles the pattern of the more diverse seven-transmembrane-domain odorant receptors. These observations suggest that GC-D may function directly in odor recognition or in modulating the sensitivity of a subpopulation of sensory neurons to specific odors.

我们克隆了膜受体鸟苷酸环化酶[GTP焦磷酸裂解酶（环化），EC 4.6.1.2]家族的另一个成员（GC-D），它在嗅觉感觉神经元的一个亚群中特异性表达。嗅觉环化酶的细胞外推定配体结合结构域在一级结构上与视网膜中表达的两种鸟苷酸环化酶相似，但与其他已知的鸟苷酸环化酶有很大差异。GC-D RNA的表达局限于嗅觉神经上皮中单个地形区域内一小群随机分散的神经元，类似于更多样化的七跨膜结构域气味受体的模式。这些观察结果表明，GC-D可能直接参与气味识别或调节感觉神经元亚群对特定气味的敏感性。