氨曲南、环丙沙星、诺氟沙星、氧氟沙星、HR 810（一种新型头孢菌素）、RU28965（一种新型大环内酯类药物）及其他药物对肠道病原体的体外比较活性。
Comparative in vitro activities of aztreonam, ciprofloxacin, norfloxacin, ofloxacin, HR 810 (a new cephalosporin), RU28965 (a new macrolide), and other agents against enteropathogens.
作者信息
Goossens H, De Mol P, Coignau H, Levy J, Grados O, Ghysels G, Innocent H, Butzler J P
出版信息
Antimicrob Agents Chemother. 1985 Mar;27(3):388-92. doi: 10.1128/AAC.27.3.388.
Abstract
The in vitro activity of drugs currently used in the treatment of diarrhea against 595 enteropathogens from worldwide sources was compared with that of six newly developed antibiotics, ciprofloxacin; norfloxacin; ofloxacin; aztreonam; HR810, an expanded-spectrum cephalosporin; and RU28965, a new macrolide. In contrast with ampicillin and chloramphenicol, trimethoprim-sulfamethoxazole showed an excellent activity against all of the enteropathogens tested, except Campylobacter species. Ciprofloxacin had the highest activity, with an overall 90% MIC of less than or equal to 0.097 micrograms/ml, except for Campylobacter species (0.39 micrograms/ml). Unlike other cephalosporins, HR810 showed a satisfactory activity against Campylobacter species (90% MIC of 3.12 micrograms/ml). RU28965 was three times less active than erythromycin against Campylobacter species.
摘要
将目前用于治疗腹泻的药物对来自世界各地的595种肠道病原体的体外活性与六种新开发的抗生素进行了比较，这六种抗生素分别是环丙沙星、诺氟沙星、氧氟沙星、氨曲南、广谱头孢菌素HR810和新型大环内酯类药物RU28965。与氨苄西林和氯霉素不同，甲氧苄啶-磺胺甲恶唑对除弯曲杆菌属外的所有测试肠道病原体均表现出优异的活性。环丙沙星活性最高，总体90%的最低抑菌浓度小于或等于0.097微克/毫升，但弯曲杆菌属除外（0.39微克/毫升）。与其他头孢菌素不同，HR810对弯曲杆菌属表现出令人满意的活性（90%的最低抑菌浓度为3.12微克/毫升）。RU28965对弯曲杆菌属的活性比红霉素低三倍。
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