Kitanishi K, Harino S, Taniguchi I, Okamoto N, Ogawa K
Department of Ophthalmology, Izumiotsu City Hospital, Osaka-fu, Japan.
Nippon Ganka Gakkai Zasshi. 1995 Mar;99(3):336-41.
Dye-filling rate of optic disc and choroid in normal human subjects was investigated using indocyanine green infra-red videoangiography and computerized image analysis. Only relative changes in the circulation of disc and choroid could be studied and the ratio (D/M) of dye-filling rate in normal subjects (age ranged 23-62) in disc (D) to choroid (M) was reliable. Intraocular pressure (IOP) was elevated to two levels with a pneumatic suction-cup. When D/M at normal IOP was 1, mean D/M was 1. 29 when mean IOP was 26.8 mmHg, and 1.48 when mean IOP was 38.4 mmHg. The results suggest that IOP elevation produced less change in the disc circulation than in the choroid. The ratio of dye-filling rate of the disc at 38.4 mmHg to normal IOP was significantly correlated (P < 0.05) with perfusion pressure at normal IOP, showing that the autoregulatory mechanisms in the disc blood flow may possibly reach the limit especially in subjects whose perfusion pressure is low.
采用吲哚菁绿红外视频血管造影术和计算机图像分析技术，对正常受试者视盘和脉络膜的染料充盈率进行了研究。仅能研究视盘和脉络膜循环的相对变化，正常受试者（年龄范围为23 - 62岁）视盘（D）与脉络膜（M）的染料充盈率之比（D/M）是可靠的。使用气动吸盘将眼压升高至两个水平。当正常眼压下D/M为1时，平均眼压为26.8 mmHg时，平均D/M为1.29，平均眼压为38.4 mmHg时，平均D/M为1.48。结果表明，眼压升高对视盘循环的影响小于对脉络膜循环的影响。38.4 mmHg时视盘染料充盈率与正常眼压时的比值与正常眼压时的灌注压显著相关（P < 0.05），表明视盘血流的自动调节机制可能尤其在灌注压低的受试者中可能达到极限。
