丹麦人、猪、牛和肉鸡中嗜热弯曲杆菌属的抗菌药敏模式。
Antimicrobial susceptibility patterns of thermophilic Campylobacter spp. from humans, pigs, cattle, and broilers in Denmark.
作者信息
Aarestrup F M, Nielsen E M, Madsen M, Engberg J
机构信息
Danish Veterinary Laboratory, Copenhagen.
出版信息
Antimicrob Agents Chemother. 1997 Oct;41(10):2244-50. doi: 10.1128/AAC.41.10.2244.
The MICs of 16 antimicrobial agents were determined for 202 Campylobacter jejuni isolates, 123 Campylobacter coli isolates, and 6 Campylobacter lari isolates from humans and food animals in Denmark. The C. jejuni isolates originated from humans (75), broilers (95), cattle (29), and pigs (3); the C. coli isolates originated from humans (7), broilers (17), and pigs (99); and the C. lari isolates originated from broilers (5) and cattle (1). All isolates were susceptible to apramycin, neomycin, and gentamicin. Only a few C. jejuni isolates were resistant to one or more antimicrobial agents. Resistance to tetracycline was more common among C. jejuni isolates from humans (11%) than among C. jejuni isolates from animals (0 to 2%). More resistance to streptomycin was found among C. jejuni isolates from cattle (10%) than among those from humans (4%) or broilers (1%). A greater proportion of C. coli than of C. jejuni isolates were resistant to the other antimicrobial agents tested. Isolates were in most cases either coresistant to tylosin, spiramycin, and erythromycin or susceptible to all three antibiotics. More macrolide-resistant isolates were observed among C. coli isolates from swine (79%) than among C. coli isolates from broilers (18%) and humans (14%). Twenty-four percent of C. coli isolates from pigs were resistant to enrofloxacin, whereas 29% of C. coli isolates from humans and none from broilers were resistant. More resistance to streptomycin was observed among C. coli isolates from swine (48%) than among C. coli isolates from broilers (6%) or humans (0%). The six C. lari isolates were susceptible to all antimicrobial agents except ampicillin and nalidixic acid. This study showed that antimicrobial resistance was found only at relatively low frequencies among C. jejuni and C. lari isolates. Among C. coli isolates, especially from swine, there was a high level of resistance to macrolides and streptomycin. Furthermore, this study showed differences in the resistance to antimicrobial agents among Campylobacter isolates of different origins.
对丹麦人类和食用动物中分离出的202株空肠弯曲菌、123株结肠弯曲菌和6株拉氏弯曲菌测定了16种抗菌药物的最低抑菌浓度（MIC）。空肠弯曲菌分离株来自人类（75株）、肉鸡（95株）、牛（29株）和猪（3株）；结肠弯曲菌分离株来自人类（7株）、肉鸡（17株）和猪（99株）；拉氏弯曲菌分离株来自肉鸡（5株）和牛（1株）。所有分离株对阿普拉霉素、新霉素和庆大霉素敏感。只有少数空肠弯曲菌分离株对一种或多种抗菌药物耐药。空肠弯曲菌分离株中，来自人类的菌株对四环素的耐药率（11%）高于来自动物的菌株（0%至2%）。空肠弯曲菌分离株中，来自牛的菌株对链霉素的耐药率（10%）高于来自人类的菌株（4%）或肉鸡的菌株（1%）。与空肠弯曲菌分离株相比，结肠弯曲菌分离株对其他受试抗菌药物的耐药率更高。在大多数情况下，分离株对泰乐菌素、螺旋霉素和红霉素要么共同耐药，要么对这三种抗生素均敏感。在来自猪的结肠弯曲菌分离株中观察到的大环内酯类耐药株比例（79%）高于来自肉鸡的菌株（18%）和人类的菌株（14%）。来自猪的结肠弯曲菌分离株中有24%对恩诺沙星耐药，而来自人类的结肠弯曲菌分离株中有29%耐药，来自肉鸡的则无耐药。在来自猪的结肠弯曲菌分离株中观察到的对链霉素的耐药率（48%）高于来自肉鸡的菌株（6%）或人类的菌株（0%）。6株拉氏弯曲菌分离株除对氨苄西林和萘啶酸耐药外，对所有抗菌药物均敏感。这项研究表明，空肠弯曲菌和拉氏弯曲菌分离株中的抗菌药物耐药率相对较低。在结肠弯曲菌分离株中，尤其是来自猪的分离株，对大环内酯类和链霉素有较高水平耐药。此外，这项研究显示不同来源的弯曲菌分离株对抗菌药物的耐药性存在差异。
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