3型副流感病毒对颗粒酶B的特异性抑制作用
Specific inhibition of granzyme B by parainfluenza virus type 3.
作者信息
Sieg S, Xia L, Huang Y, Kaplan D
机构信息
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106-4943, USA.
出版信息
J Virol. 1995 Jun;69(6):3538-41. doi: 10.1128/JVI.69.6.3538-3541.1995.
Abstract
T-cell-mediated cytotoxicity is an important means of defense against viral pathogens; however, several viruses possess mechanisms to disrupt cytotoxicity, thereby allowing them to avoid immune clearance. These viruses have been shown to inhibit cytotoxicity by interfering with the capacity of T lymphocytes to specifically recognize infected cells. An alternative mechanism for virally induced cytotoxic dysfunction is identified in this report. We show that parainfluenza virus type 3, a negative-stranded RNA virus, can inhibit cytotoxicity by causing a defect in the cytotoxic effector apparatus. This defect is identified as a selective inhibition of granzyme B mRNA.
摘要
T细胞介导的细胞毒性是抵御病毒病原体的重要防御手段；然而，几种病毒拥有破坏细胞毒性的机制，从而使其能够避免免疫清除。这些病毒已被证明可通过干扰T淋巴细胞特异性识别受感染细胞的能力来抑制细胞毒性。本报告中确定了病毒诱导的细胞毒性功能障碍的另一种机制。我们发现，负链RNA病毒3型副流感病毒可通过导致细胞毒性效应器装置缺陷来抑制细胞毒性。这种缺陷被确定为颗粒酶B mRNA的选择性抑制。
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本文引用的文献
1
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Nature. 1994 Jun 2;369(6479):407-10. doi: 10.1038/369407a0.
2
Modulation of major histocompatibility complex antigen expression by viral infection.病毒感染对主要组织相容性复合体抗原表达的调节作用。
Am J Pathol. 1994 Apr;144(4):637-50.
3
Human cytomegalovirus-infected cells have unstable assembly of major histocompatibility complex class I complexes and are resistant to lysis by cytotoxic T lymphocytes.人巨细胞病毒感染的细胞具有不稳定的主要组织相容性复合体I类复合物组装，并且对细胞毒性T淋巴细胞的裂解具有抗性。
J Virol. 1994 May;68(5):2822-9. doi: 10.1128/JVI.68.5.2822-2829.1994.
4
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.细胞毒性淋巴细胞在同种异体靶细胞中快速诱导DNA片段化和凋亡需要颗粒酶B。
Cell. 1994 Mar 25;76(6):977-87. doi: 10.1016/0092-8674(94)90376-x.
5
Infection and immunoregulation of T lymphocytes by parainfluenza virus type 3.3型副流感病毒对T淋巴细胞的感染及免疫调节
Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6293-7. doi: 10.1073/pnas.91.14.6293.
6
Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants.天然存在的HIV-1 Gag变体对抗细胞毒性T细胞活性。
Nature. 1994 Jun 2;369(6479):403-7. doi: 10.1038/369403a0.
7
Viruses disrupt functions of human lymphocytes. Effects of measles virus and influenza virus on lymphocyte-mediated killing and antibody production.病毒会破坏人类淋巴细胞的功能。麻疹病毒和流感病毒对淋巴细胞介导的杀伤作用及抗体产生的影响。
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8
Evidence for the persistence of paramyxoviruses in human bone marrows.
J Gen Virol. 1984 Nov;65 ( Pt 11):1881-8. doi: 10.1099/0022-1317-65-11-1881.
9
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10
Persistent parainfluenza virus shedding during isolation at the South Pole.
Nature. 1981 Jan 15;289(5794):187-9. doi: 10.1038/289187a0.
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