白细胞介素-10在抑制3型副流感病毒介导的T细胞增殖和凋亡中的作用
The role of interleukin-10 in the inhibition of T-cell proliferation and apoptosis mediated by parainfluenza virus type 3.
作者信息
Sieg S, King C, Huang Y, Kaplan D
机构信息
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106-4943, USA.
出版信息
J Virol. 1996 Jul;70(7):4845-8. doi: 10.1128/JVI.70.7.4845-4848.1996.
Abstract
We have previously demonstrated that parainfluenza virus type 3 (PIV3), a significant respiratory pathogen, can markedly inhibit T-cell function in vitro. We now report that the virus potently induces interleukin-10 (IL-10) production by peripheral blood mononuclear cells. The IL-10 produced contributes to viral inhibition of T-cell proliferation and protects T cells from PIV3-mediated apoptosis. These findings suggest that IL-10 is likely to play an important immunoregulatory role in PIV3 infections.
摘要
我们之前已经证明，3型副流感病毒（PIV3）作为一种重要的呼吸道病原体，在体外能显著抑制T细胞功能。我们现在报告，该病毒能强力诱导外周血单核细胞产生白细胞介素-10（IL-10）。所产生的IL-10有助于病毒对T细胞增殖的抑制，并保护T细胞免受PIV3介导的凋亡。这些发现表明，IL-10可能在PIV3感染中发挥重要的免疫调节作用。
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