Milman N, Clausen J O, Jordal R
Department of Medicine, Oresund Hospital, Hørsholm, Denmark.
Ann Hematol. 1995 Apr;70(4):215-21. doi: 10.1007/BF01700378.
Iron status was assessed by measurement of serum (S-) ferritin and hemoglobin (Hb) in 548 randomly selected healthy Danes (264 men, 284 women) with a median age of 25 years (range 16-31). S-ferritin values in men displayed a gradual increase with age, and at all ages, men had higher values than women. Iron deficiency (i.e., S-ferritin < 16 micrograms/l) was observed in 0.8%; none had iron deficiency anemia (i.e., S-ferritin < 16 micrograms/l and Hb < 129 g/l). Daily iron supplementation was used by 15.5%. The frequency of iron deficiency was 0% in supplement users vs 0.9% in nonusers. The frequency of preclinical hereditary hemochromatosis was 0.38%. There was a slight insignificant increase in S-ferritin values of women with age. Iron deficiency was observed in 14.7% of 16- to 19-year-olds, in 9.2% of 20- to 24-year-olds, and in 8.6% of 25- to 31-year-old women (p < 0.01), and iron deficiency anemia (i.e., S-ferritin < 16 micrograms/l and Hb < 121 g/l) in 14.7%, 3.4%, and 3.7%, respectively (p < 0.01). Daily iron supplementation was used by 21.5%. The frequency of iron deficiency in users was 4.9% vs. 10.8% in nonusers, and the frequency of iron deficiency anemia 1.6% in users vs. 5.8% in nonusers. The results indicate a satisfactory iron status in young men. There is a high frequency of iron deficiency in young women, suggesting that preventive measures should be considered in this risk group.
通过检测血清铁蛋白（S-铁蛋白）和血红蛋白（Hb），对548名随机选取的健康丹麦人（264名男性，284名女性）进行铁状态评估，这些人的年龄中位数为25岁（范围16 - 31岁）。男性的S-铁蛋白值随年龄逐渐升高，且在所有年龄段，男性的值均高于女性。观察到0.8%的人缺铁（即S-铁蛋白<16微克/升）；无人患缺铁性贫血（即S-铁蛋白<16微克/升且Hb<129克/升）。15.5%的人每日补充铁剂。补充铁剂者缺铁频率为0%，未补充者为0.9%。临床前遗传性血色素沉着症的频率为0.38%。女性的S-铁蛋白值随年龄略有增加，但无统计学意义。16至19岁女性中有14.7%缺铁，20至24岁女性中有9.2%缺铁，25至31岁女性中有8.6%缺铁（p<0.01），缺铁性贫血（即S-铁蛋白<16微克/升且Hb<121克/升）的比例分别为14.7%、3.4%和3.7%（p<0.01）。21.5%的人每日补充铁剂。补充铁剂者缺铁频率为4.9%，未补充者为10.8%；补充铁剂者缺铁性贫血频率为1.6%，未补充者为5.8%。结果表明年轻男性的铁状态良好。年轻女性缺铁频率较高，提示应对该风险群体考虑采取预防措施。
