Henseler T, Christophers E
Department of Dermatology, University of Kiel, Germany.
J Am Acad Dermatol. 1995 Jun;32(6):982-6. doi: 10.1016/0190-9622(95)91336-x.
Psoriasis is a multifactorial disease of unknown origin.
Our purpose was to determine the frequency of skin disorders concomitantly seen in patients with psoriasis.
We analyzed data from more than 40,000 patients and calculated sex- and age-adjusted ratios of expected and observed incidence rates of associated disorders.
The results demonstrate that, compared with age-matched control patients without psoriasis, cutaneous immune disorders such as allergic contact dermatitis, atopic dermatitis, and urticaria are underrepresented in patients with psoriasis. In contrast, certain systemic disorders such as diabetes, heart insufficiency, and obesity occur significantly more often in patients with psoriasis than in control subjects. Increased resistance to cutaneous bacterial infections was noted only in patients with early-onset psoriasis.
Our observations show that a distinct pattern of associated diseases exists in patients with psoriasis. Although systemic disorders such as obesity, diabetes, and heart disease may be related to dietary habits and nutritional status, the relative resistance to cutaneous infections together with decreased immune responsiveness suggest a genetically determined selection.
银屑病是一种病因不明的多因素疾病。
我们的目的是确定银屑病患者中同时出现的皮肤疾病的发生率。
我们分析了40000多名患者的数据，并计算了相关疾病预期发病率和观察发病率的性别及年龄调整比率。
结果表明，与年龄匹配的无银屑病对照患者相比，银屑病患者中过敏性接触性皮炎、特应性皮炎和荨麻疹等皮肤免疫疾病的发生率较低。相比之下，银屑病患者中某些全身性疾病，如糖尿病、心力衰竭和肥胖症的发生率明显高于对照受试者。仅在早发性银屑病患者中观察到皮肤细菌感染抵抗力增强。
我们的观察结果表明，银屑病患者存在独特的相关疾病模式。尽管肥胖、糖尿病和心脏病等全身性疾病可能与饮食习惯和营养状况有关，但对皮肤感染的相对抵抗力以及免疫反应性降低提示存在遗传决定的选择。
