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[达喀尔皮金(塞内加尔)大规模初次抗狂犬病疫苗接种(灭活疫苗)后犬的血清学反应]

[Serologic response in dogs after a mass primary antirabies vaccination (inactivated vaccine) at Pikine Dakar (Senegal)].

作者信息

Akakpo A J, Mbou G, Bornarel P, Sarradin P, Bada Alambjedi R

出版信息

Dakar Med. 1993;38(2):123-8.

PMID:7758368
Abstract

Mass antirabic vaccination campaign, allowed in 1987, the immunization of 514 pet dogs against rabies at Pikine, a suburban area of Dakar. Dogs received one subcutaneous dose of inactivated tissue culture rabies vaccine (RABISIN, Rhône Mérieux France). Mean antibodies titles in ELISA on days 30, 180 and 360 after vaccination, are respectively 4.78; 1.55 and 0.25 IU/ml. In the same time the proportions of protected animals are 74%, 81% and 7%. This results is compared with those obtained in other countries. The rapid decrease of antibodies suggest the role of poor general health of animals such as malnutrition, infections, external and internal parasitemia.

摘要

1987年开展了大规模抗狂犬病疫苗接种运动,在达喀尔郊区皮金对514只宠物狗进行了狂犬病免疫接种。这些狗皮下注射了一剂法国罗纳-梅里厄公司生产的灭活组织培养狂犬病疫苗(RABISIN)。接种后第30天、180天和360天,ELISA法检测的平均抗体效价分别为4.78;1.55和0.25 IU/ml。同时,受保护动物的比例分别为74%、81%和7%。将这一结果与其他国家获得的结果进行了比较。抗体的迅速下降表明动物总体健康状况不佳,如营养不良、感染、体内外寄生虫血症等因素起到了作用。

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