Romero C H, Barrett T, Kitching R P, Bostock C, Black D N
BBSRC Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK.
Vaccine. 1995 Jan;13(1):36-40. doi: 10.1016/0264-410x(95)80008-2.
Goats were protected against a lethal challenge of peste des petits ruminants (PPR) virus following vaccination with a recombinant capripoxvirus containing either the fusion (F) gene of rinderpest virus or the haemagglutinin (H) gene of rinderpest virus. The H gene recombinant produced high titres of neutralizing antibody to rinderpest virus in the vaccinated goats, whereas the F gene recombinant failed to stimulate detectable levels of neutralizing antibody. A similar response to the two recombinant vaccines has previously been reported for cattle. Neither recombinant produced detectable levels of specific antibodies to PPR virus.
用含有牛瘟病毒融合（F）基因或牛瘟病毒血凝素（H）基因的重组山羊痘病毒疫苗接种后，山羊对小反刍兽疫（PPR）病毒的致死性攻击具有保护作用。H基因重组体在接种疫苗的山羊中产生了高滴度的针对牛瘟病毒的中和抗体，而F基因重组体未能刺激产生可检测水平的中和抗体。此前已有报道称牛对这两种重组疫苗有类似反应。两种重组体均未产生可检测水平的针对PPR病毒的特异性抗体。
