Kovalev G I, Tomnikov A M, Muzlaev G G
Zh Vopr Neirokhir Im N N Burdenko. 1995 Jan-Mar(1):13-5.
Hemosorption as part of intensive therapy was made in 24 patients with severe and moderate craniocerebral injury. Due to the influence of toxic factors on the mechanisms responsible for the development of immune depression, the performance of the immune system could be normalized by disintoxication therapy as a tool of pathogenetic action on the main mechanisms of development of a pathological process. The investigations showed that the more effective the endogenous intoxication syndrome was levelled in craniocerebral injury, to the higher extent the major immunological parameters became normal in the shortest periods of time. Hemosorption substantially made the course of a traumatic disease milder by enhancing the efficiency of therapy for endotoxicosis. This effect mainly appeared as normalized metabolism and increased immune defense. Hemosorption improved the course of inflammatory complications, as evidenced by clinical features and laboratory findings. Hemosorption is effective prior to the occurrence of signs of clinical decompensation.
对24例重度和中度颅脑损伤患者进行了血液吸附治疗，作为强化治疗的一部分。由于毒性因素对免疫抑制发生机制的影响，作为对病理过程主要发展机制进行病因学作用的一种工具，解毒疗法可使免疫系统功能恢复正常。研究表明，在颅脑损伤中内源性中毒综合征缓解得越有效，主要免疫参数在最短时间内恢复正常的程度就越高。血液吸附通过提高对内毒素血症的治疗效果，显著减轻了创伤性疾病的病程。这种效果主要表现为代谢正常化和免疫防御增强。临床特征和实验室检查结果证明，血液吸附改善了炎症并发症的病程。在出现临床失代偿迹象之前，血液吸附是有效的。
