黑曲霉SK 9317对多环芳烃芘的代谢
Metabolism of the polycyclic aromatic hydrocarbon pyrene by Aspergillus niger SK 9317.
作者信息
Wunder T, Kremer S, Sterner O, Anke H
机构信息
University of Kaiserslautern, Department of Biotechnology, Germany.
出版信息
Appl Microbiol Biotechnol. 1994 Dec;42(4):636-41. doi: 10.1007/BF00173932.
The metabolism of pyrene, a polycyclic aromatic hydrocarbon consisting of four rings, by Aspergillus niger SK 9317 was investigated. The metabolites formed were isolated and identified as 1-hydroxypyrene, 1,6- and 1,8-pyrenequinone, 1,6- and 1,8-dihydroxypyrene, 1-pyrenyl sulphate and 1-hydroxy-8-pyrenyl sulphate. This is the first report of 1-hydroxy-8-pyrenyl as a metabolite in the microbial metabolism of pyrene. The results suggest that A. niger metabolizes pyrene by cytochrome P-450 monooxygenase enzyme systems.
研究了黑曲霉SK 9317对芘（一种由四个环组成的多环芳烃）的代谢情况。分离出形成的代谢产物，并鉴定为1-羟基芘、1,6-和1,8-芘醌、1,6-和1,8-二羟基芘、1-芘基硫酸盐和1-羟基-8-芘基硫酸盐。这是关于1-羟基-8-芘基作为芘微生物代谢产物的首次报道。结果表明，黑曲霉通过细胞色素P-450单加氧酶系统代谢芘。
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