LMP1在上皮细胞中的表达导致NF-κB/Rel家族蛋白的一个特定亚群被激活。
Expression of LMP1 in epithelial cells leads to the activation of a select subset of NF-kappa B/Rel family proteins.
作者信息
Paine E, Scheinman R I, Baldwin A S, Raab-Traub N
机构信息
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7295, USA.
出版信息
J Virol. 1995 Jul;69(7):4572-6. doi: 10.1128/JVI.69.7.4572-4576.1995.
Abstract
This study demonstrates that the Epstein-Barr virus protein LMP1 activates a specific subset of NF-kappa B/Rel proteins in the C33 epithelial cell line. Western immunoblot analysis used to analyze the intracellular distribution and abundance of the proteins present in these complexes demonstrated that levels of the p50 and p52 proteins were significantly elevated in the nuclei of LMP1-expressing cells. The data also suggest that LMP1 facilitates the translocation of p50 to the nucleus and may affect the processing of the p100 and p105 precursor proteins or the stability of p52 and p50.
摘要
本研究表明，爱泼斯坦-巴尔病毒蛋白LMP1在C33上皮细胞系中激活了NF-κB/Rel蛋白的一个特定亚群。用于分析这些复合物中蛋白质的细胞内分布和丰度的Western免疫印迹分析表明，在表达LMP1的细胞的细胞核中，p50和p52蛋白的水平显著升高。数据还表明，LMP1促进p50向细胞核的转运，并可能影响p100和p105前体蛋白的加工或p52和p50的稳定性。
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