Novak V, Novak P, deMarchie M, Schondorf R
Department of Neurosciences, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec, Canada.
Clin Auton Res. 1995 Feb;5(1):24-30. doi: 10.1007/BF01845495.
To determine whether an intact brainstem is essential for the generation of neurogenically mediated fluctuations of R-R intervals and blood pressure, three patients with cerebellar lesions causing severe brainstem compression or death, one patient with a large pontine infarct and one patient with a pontine haemorrhage, were studied. Time-frequency maps (based on a modified Wigner distribution) were constructed from blood pressure and R-R interval signals in these patients with brainstem injury and were compared with maps of normal control subjects. Low frequency sympathetically mediated rhythms (0.01-0.12 Hz) in systolic and diastolic pressure remained detectable but attenuated in patients with brainstem injury whereas there was an almost complete loss of normal R-R intervals rhythmicity over 0.01 to 0.5 Hz range. These data suggest that fluctuations in R-R intervals require an intact brainstem, whereas low frequency approximately 0.06 +/- 0.02 Hz blood pressure rhythms may be preserved by spinal sympathetic circuitry.
为了确定完整的脑干对于神经源性介导的R-R间期和血压波动的产生是否至关重要，我们研究了三名因小脑病变导致严重脑干受压或死亡的患者、一名大面积脑桥梗死患者和一名脑桥出血患者。根据这些脑干损伤患者的血压和R-R间期信号构建了时频图（基于改良的维格纳分布），并与正常对照受试者的图进行了比较。收缩压和舒张压中低频交感神经介导的节律（0.01-0.12Hz）在脑干损伤患者中仍可检测到但有所减弱，而在0.01至0.5Hz范围内正常R-R间期的节律几乎完全丧失。这些数据表明，R-R间期的波动需要完整的脑干，而低频约0.06±0.02Hz的血压节律可能由脊髓交感神经回路保留。
