Vilcek J, Havell E A, Kohase M
J Infect Dis. 1976 Jun;133 Suppl:A22-9. doi: 10.1093/infdis/133.supplement_2.a22.
Ten years have passed since cycloheximide was first shown to enhance endotoxin-induced production of interferon in mice, in the first demonstration of what was later called the superinduction of interferon. Various inhibitors of protein and RNA symthesis, as well as combinations of these inhibitors, have been shown to act as superinducing agents of interferon production stimulated by polyriboinosinic-polyribocytidylic acid. The evidence that superinduction is due to the suppression of a mechanism of post-transcriptional regulation of interferon synthesis is rather convincing. The notion (first proposed about six years ago) that this modification is caused by a protein "repressor" remains the most plausible, albeit still unproved, hypothesis. The availability of systems that translate with fidelity interferon messenger RNA isolated from induced cells should prove most useful in the elucidation of post-transcriptional control mechanisms of interferon synthesis and of interferon superinduction. Meanwhile, superinduction has become a useful tool for the production of large quantities of interferon. In particular, this technique has been successfully applied to the production of interferon from human diploid fibroblasts. The clinical potential of this material remains to be critically examined.
自环己酰亚胺首次被证明能增强内毒素诱导的小鼠干扰素产生以来，已经过去了十年，这是后来被称为干扰素超诱导现象的首次证明。各种蛋白质和RNA合成抑制剂，以及这些抑制剂的组合，已被证明可作为聚肌苷酸-聚胞苷酸刺激的干扰素产生的超诱导剂。超诱导是由于抑制了干扰素合成的转录后调节机制这一证据相当有说服力。这种修饰是由一种蛋白质“阻遏物”引起的这一观点（大约六年前首次提出）仍然是最合理的假设，尽管尚未得到证实。能够准确翻译从诱导细胞中分离出的干扰素信使RNA的系统，对于阐明干扰素合成的转录后控制机制和干扰素超诱导现象应该是非常有用的。与此同时，超诱导已成为生产大量干扰素的一种有用工具。特别是，这项技术已成功应用于从人类二倍体成纤维细胞生产干扰素。这种物质的临床潜力仍有待严格审查。
