Hughes T K, Blalock J E, McKerlie M L, Baron S
Infect Immun. 1981 May;32(2):454-7. doi: 10.1128/iai.32.2.454-457.1981.
A newly recognized cell-produced viral inhibitor appeared to be spontaneously released from most cells in tissue culture. It strongly inhibited the replication of a variety of viruses but did not exhibit species specificity as does interferon. These studies on the inhibitor's mechanism of action indicated that it inhibited attachment and penetration of virus by a readily reversible reaction requiring the presence of both virus and cells. Studies of inactivation by specific enzymes or chemicals indicated that for activity the inhibitor required intact protein but not lipid, carbohydrate, deoxyribonucleic acid, or ribonucleic acid.
一种新发现的细胞产生的病毒抑制剂似乎在组织培养中能从大多数细胞中自发释放出来。它能强烈抑制多种病毒的复制，但不像干扰素那样具有种属特异性。对该抑制剂作用机制的研究表明，它通过一种需要病毒和细胞同时存在的易于逆转的反应来抑制病毒的附着和穿透。对其被特定酶或化学物质灭活的研究表明，该抑制剂发挥活性需要完整的蛋白质，而不需要脂质、碳水化合物、脱氧核糖核酸或核糖核酸。
