Ogiso M, Komoto M, Okinaga T, Koyota S, Hoshi M
PRESTO, Research Development Corporation of Japan (JRDC), Tokyo.
Exp Eye Res. 1995 Mar;60(3):317-23. doi: 10.1016/s0014-4835(05)80113-7.
We previously reported that human lens accumulates gangliosides in association with aging and senile cataract progression. Structural analysis revealed that gangliosides in human cataractous lenses were composed of ganglio-series gangliosides, such as GM3, GM2, GM1 and GD1a, and sialyl-Lewisx-containing neolacto-series gangliosides. Although Lewisx-containing neolacto-series glycolipid was found to accumulate in association with aging and cataract progression, the sialyl-Lewisx gangliosides did not show much accumulation in individual lenses from subjects between 16 and 80 years old. The content of sialyl-Lewisx gangliosides was about two to four times higher than that of Lewisx glycolipids, suggesting the possibility that the increase in Le(x) glycolipid is partly due to the desialylation of sialyl-Le(x) gangliosides. On the other hand, the expression of ganglio-series gangliosides increased in an age-related manner. Thus, age-related changes in lens glycolipids may modify the cell-to-cell interaction induced by cell surface sugar chains, leading to the initiation and progression of cataract.
我们之前报道过，随着衰老和老年性白内障的进展，人晶状体中神经节苷脂会累积。结构分析显示，人白内障晶状体中的神经节苷脂由神经节系列神经节苷脂（如GM3、GM2、GM1和GD1a）以及含唾液酸化路易斯x的新乳糖系列神经节苷脂组成。尽管发现含路易斯x的新乳糖系列糖脂会随着衰老和白内障进展而累积，但在16至80岁受试者的单个晶状体中，唾液酸化路易斯x神经节苷脂并未显示出大量累积。唾液酸化路易斯x神经节苷脂的含量比路易斯x糖脂高约两到四倍，这表明Le(x)糖脂增加部分可能是由于唾液酸化Le(x)神经节苷脂的去唾液酸化作用。另一方面，神经节系列神经节苷脂的表达呈年龄相关性增加。因此，晶状体糖脂的年龄相关性变化可能会改变由细胞表面糖链诱导的细胞间相互作用，从而导致白内障的发生和进展。
