Jasnoch V, Ernst K, Hundeiker M
Fachklinik Hornheide, Dermatologie, Westfälische Wilhelms-Universität, Münster.
Hautarzt. 1995 Apr;46(4):244-9. doi: 10.1007/s001050050248.
Keratoacanthomas are made up of the same spinocellular differentiated cell material as squamous cell carcinomas, but they differ from the latter in origin and growth properties. The majority--in our series 98% of 741 examined cases--are of the "crateriform" type, which after rapid growth during the initial stage give way to spontaneous regression, mostly with complete restoration of the cutaneous structure. Less than 2% belong to the rare destructive variants with disturbed or absent regression and persistent invasive growth. Keratoacanthoma marginatum centrifugum, mutilating keratoacanthomas and aggregated keratoacanthomas can lead to extremely severe defects. None of the "conservative" treatment methods recommended in the literature up to now has proved effective, with the exception of surgery and radiotherapy with tumour ratio doses. Many publications are obviously based on uncritically interpreted individual observations.
角化棘皮瘤与鳞状细胞癌一样，由相同的棘细胞分化细胞物质组成，但它们在起源和生长特性上与后者不同。大多数——在我们的系列研究中，741例受检病例中的98%——属于“火山口状”类型，在初始阶段快速生长后会自发消退，大多数情况下皮肤结构会完全恢复。不到2%属于罕见的破坏性变体，消退受阻或没有消退，持续侵袭性生长。离心性边缘性角化棘皮瘤、毁形性角化棘皮瘤和聚集性角化棘皮瘤可导致极其严重的缺损。到目前为止，文献中推荐的“保守”治疗方法，除了手术和肿瘤比例剂量的放射治疗外，没有一种被证明是有效的。许多出版物显然是基于未经批判性解释的个别观察结果。
