Gräf M, Wassill H, Dick B
Univ-Augenklinik für Schielbehandlung und Neuroophthalmologie Giessen.
Klin Monbl Augenheilkd. 1995 Apr;206(4):255-61. doi: 10.1055/s-2008-1035435.
A new position-independent and portable Mackay-Marg-tonometer in miniature, the so-called ProTon (PT), was compared with reference to its clinical usefulness with the Goldmann applanation tonometer (GAT), being a commonly accepted reference.
The intraocular pressure (IOP) in 164 eyes of 85 adults (patients and volunteers without ocular disease) was measured using the sequence GAT, PT and again GAT--each three times in a row-by three different investigators in a randomized scheme. In an attempt to detect any systemic influence, the difference obtained by subtracting the value measured using PT from the value attained using GAT was compared to the central corneal thickness and radius. Moreover, the central IOP readings were compared with the peripheral IOP in 60 eyes of 30 volunteers measured by PT, to detect any possible influence of the locality of measurement. Dependence of measurement on individual influences was examined by comparing PT-values obtained by each investigator.
Linear regression analysis between PT (y-axis) and GAT (x-axis) for an IOP range of 0 to 62 mm Hg resulted in the following equation: PT = 1.036 x GAT -2.00 with a PT value standard deviation of 1.65 mm Hg (r = 0.988; p < 0.0001). Reproducibility of each of the three PT-values (mean pair difference of 1.1 mm Hg) corresponded to the analogous first two GAT-values (differences 1.0 up to 1.2 mm Hg). The mean IOP-value of 1) the GAT measurements (1 to 3) was 18.35 mm Hg, 2) of the last three GAT measurements, 17.15 mm Hg and 3) of all PT-measurements, 16.40 mm Hg. No statistical difference was found between the IOP measured centrally and peripherally. A clinically nonsignificant dependency for PT-readings on the examiner was verified.
Due to the high reproducibility, independency on examiner and acceptable correspondence of PT with GAT values, the PT appears to be a promising new development for use in measuring intraocular pressure. It will be necessary to modify the calibration of PT since IOP measured systematically about 2 mm Hg too low.
一种新型的与位置无关且便携的微型Mackay-Marg眼压计，即所谓的ProTon（PT），与被广泛认可的参考眼压计Goldmann压平眼压计（GAT）相比，评估其临床实用性。
85名成年人（无眼部疾病的患者和志愿者）的164只眼睛的眼压，由三名不同的研究人员按照随机方案，依次使用GAT、PT测量，然后再次使用GAT测量——每次连续测量三次。为了检测任何系统性影响，将用GAT测量的值减去用PT测量的值所得到的差值与中央角膜厚度和半径进行比较。此外，将30名志愿者的60只眼睛通过PT测量的中央眼压读数与周边眼压进行比较，以检测测量位置的任何可能影响。通过比较每位研究人员获得的PT值，检查测量对个体影响的依赖性。
眼压范围在0至62 mmHg之间时，PT（纵轴）与GAT（横轴）的线性回归分析得出以下方程：PT = 1.036×GAT - 2.00，PT值标准差为1.65 mmHg（r = 0.988；p < 0.0001）。三个PT值中每个值的可重复性（平均配对差值为1.1 mmHg）与前两个类似的GAT值（差值为1.0至1.2 mmHg）相当。1）GAT测量（第1至3次）的平均眼压值为18.35 mmHg，2）最后三次GAT测量的平均眼压值为17.15 mmHg，3）所有PT测量的平均眼压值为16.40 mmHg。中央和周边测量的眼压之间未发现统计学差异。验证了PT读数对检查者的临床无显著依赖性。
由于PT具有高可重复性、不依赖检查者且与GAT值具有可接受的一致性，PT似乎是用于测量眼压的一项有前景的新进展。由于系统测量的眼压约低2 mmHg，因此有必要对PT的校准进行修改。
