Scofield R H, Kurien B, Gross T, Warren W L, Harley J B
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
Lancet. 1995 Jun 17;345(8964):1542-4. doi: 10.1016/s0140-6736(95)91089-1.
The spondyloarthropathies are associated by an unknown mechanism with HLA-B27 and certain bacteria. HLA-B27 shares sequence with proteins from enteric bacteria. The B*2705 sequence contains a nonapeptide, LRRYLENGK, predicted to bind in the binding cleft of B27. Some nonapeptides from enteric organisms that share sequence with this nonapeptide of B27 also bind B27. These observations suggest an unappreciated mechanism for autoimmunity that may operate in the B27-associated spondyloarthropathies involving peptides bound to and derived from histocompatibility alleles.
脊柱关节病通过一种未知机制与HLA - B27及某些细菌相关联。HLA - B27与肠道细菌的蛋白质有共同序列。B*2705序列包含一个九肽LRRYLENGK，预计可结合于B27的结合裂隙中。一些来自肠道微生物且与B27的该九肽有共同序列的九肽也能结合B27。这些观察结果提示了一种未被充分认识的自身免疫机制，该机制可能在涉及与组织相容性等位基因结合并源自这些等位基因的肽的B27相关脊柱关节病中发挥作用。
