Cherrie J W, Robertson A
Institute of Occupational Medicine, Edinburgh, U.K.
Ann Occup Hyg. 1995 Jun;39(3):387-92. doi: 10.1016/0003-4878(95)00016-8.
Dermal uptake of hazardous substances is dependent on the concentration of the material on the surface of the skin rather than its mass. It is suggested that it would be appropriate to consider the integral of concentration, over the skin surface and throughout the exposure duration, as an appropriate index of dermal exposure. For a low volatility substance this exposure index would correspond to the product of concentration, area of skin exposed and the duration of exposure. For volatile materials the magnitude of the exposure index would additionally depend on the loss of the substance by evaporation. This dermal exposure index is more likely to reflect the contribution to the overall dose received from the skin than the previously used determinations of mass of hazardous substance on the skin. Suggestions are made for possible methods of making measurements using this index.
有害物质经皮肤吸收取决于皮肤表面物质的浓度而非其质量。有人建议，将皮肤表面及整个暴露期间的浓度积分作为皮肤暴露的合适指标是恰当的。对于低挥发性物质，该暴露指标相当于浓度、暴露皮肤面积和暴露持续时间的乘积。对于挥发性物质，暴露指标的大小还将取决于物质的蒸发损失。与之前使用的皮肤表面有害物质质量测定方法相比，这种皮肤暴露指标更有可能反映对经皮肤接收的总剂量的贡献。文中针对使用该指标进行测量的可能方法提出了建议。
