Bellman B, Gregory N A, Silvers D, Fountain K S
University of Miami School of Medicine, Department of Dermatology and Cutaneous Surgery, Florida, USA.
Cutis. 1995 Apr;55(4):221-4.
A 68-year-old white man presented to the inpatient service at Columbia-Presbyterian Hospital with a chief complaint of a progressively enlarging tumor of the right infraorbital region for many years and multiple, pink papulonodules on his head, neck, and trunk. A biopsy specimen of the right infraorbital and back lesions demonstrated an infiltrating adenocarcinoma with prominent signet ring cells, and small lumen formation. Results of an extensive work-up revealed bone marrow metastases and no evidence of a primary malignancy. We present a case of primary sweat gland carcinoma with metastases to the skin based upon history, clinical presentation, results of physical examination, histopathologic examination, immunohistochemical studies, and response to 5-fluorouracil chemotherapy. Due to the rarity of the tumor, the diagnosis is usually not made until the tumor(s) is invasive. An excellent response to systemic chemotherapy with 5-fluorouracil in metastatic sweat gland carcinoma was noted in this case.
一名68岁白人男性因右眶下区域肿瘤多年来逐渐增大以及头、颈和躯干出现多个粉红色丘疹结节为主诉入住哥伦比亚长老会医院。右眶下及背部病变的活检标本显示为浸润性腺癌，伴有显著印戒细胞和小腔隙形成。全面检查结果显示存在骨髓转移且无原发性恶性肿瘤证据。基于病史、临床表现、体格检查结果、组织病理学检查、免疫组化研究以及对5-氟尿嘧啶化疗的反应，我们报告一例原发性汗腺癌转移至皮肤的病例。由于该肿瘤罕见，通常在肿瘤发生浸润时才得以诊断。本病例中观察到转移性汗腺癌对5-氟尿嘧啶全身化疗有良好反应。
