Smith E B
Department of Clinical Biochemistry, University of Aberdeen, Foresterhill, U.K.
Eur Heart J. 1995 Mar;16 Suppl A:11-4; discussion 14-5. doi: 10.1093/eurheartj/16.suppl_a.11.
Virtually all plasma proteins, including fibrinogen, low density lipoprotein and lipoprotein(a), are present in normal arterial intima and in atherosclerotic lesions, and their concentrations are related to plasma concentrations. Fibrin is also a significant component of many lesions, particularly early proliferative (gelatinous) lesions, where it may be muscle cells migrate and proliferate, bind thrombin, and are a source of fibrin degradation products (FDPs), which are mitogenic. Very recent studies suggest that free a-thrombin may be present in lesions despite an apparent excess of antithrombin III, so this may promote fibrin formation within the lesion. Furthermore, fibrinolysis and FDP generation may be mediated by catheptic enzymes in addition to plasmin.
几乎所有血浆蛋白，包括纤维蛋白原、低密度脂蛋白和脂蛋白(a)，都存在于正常动脉内膜和动脉粥样硬化病变中，其浓度与血浆浓度相关。纤维蛋白也是许多病变的重要组成部分，尤其是早期增殖性（胶状）病变，在这些病变中，肌肉细胞可能迁移和增殖、结合凝血酶，并且是有丝分裂原性的纤维蛋白降解产物（FDPs）的来源。最近的研究表明，尽管抗凝血酶III明显过量，但病变中可能存在游离α-凝血酶，因此这可能促进病变内纤维蛋白的形成。此外，除了纤溶酶外，纤维蛋白溶解和FDP生成可能由组织蛋白酶介导。
