Chen I S, Wu S J, Tsai I L
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
J Nat Prod. 1994 Sep;57(9):1206-11. doi: 10.1021/np50111a003.
Two new benzo[c]phenanthridine alkaloids, 6-methyldihydrochelerythrine [1] and 6-methylnorchelerythrine [2], together with 23 known compounds, were isolated from the root bark of Zanthoxylum simulans. Structures were elucidated by spectral analysis. Among them, the pyranoquinoline alkaloids, zanthosimuline [3], and huajiaosimuline [4], exhibited cytotoxic activity. In addition, compound 4 showed significant antiplatelet aggregation activity and induced terminal differentiation with cultured HL-60 cells.
从青花椒的根皮中分离出两种新的苯并[c]菲啶生物碱，6-甲基二氢白屈菜红碱[1]和6-甲基去甲白屈菜红碱[2]，以及23种已知化合物。通过光谱分析阐明了其结构。其中，吡喃喹啉生物碱花椒素[3]和花椒辛素[4]表现出细胞毒性活性。此外，化合物4显示出显著的抗血小板聚集活性，并能诱导培养的HL-60细胞终末分化。
