Bilabina I, Brazier M, Bour H, Doh A, Desmet G
Laboratoire de Biochimie et de Nutrition appliquées, Faculté des Sciences, Université du Bénin, Lomé, Togo.
Ann Biol Clin (Paris). 1994;52(4):261-4.
A pilot study was carried out in two Togolese localities (Gobe, Moretan) situated in an endemic goiter area. The aim of this work was to collect laboratory and nutritional data to assess and follow up campaigns against iodide deficiency. Ninety-seven urine samples were analysed. We studied the urinary excretion and the iodine concentration of important diet substances (water and salt) using an optimized potentiometric method. Mean values of urinary iodide/creatinine ratios (microgram/g) observed in the two Togolese localities were respectively 34.1 +/- 6.3 in Gobe and 39.2 +/- 6.4 in Moretan. These low values differ significantly (P < 10(-9)) from the physiological values determined in Amiens, France (147.5 +/- 56.3). The drinking water of the two localities showed a low iodide concentration (2 micrograms/l). The iodide concentration of cooking salts was also low (< 0.2 mg/kg) compared with iodized salt used in France (11.2 +/- 0.2 mg/kg) These results show an iodide deficiency in both localities, probably due to the lack of iodide in the local diet. Iodide determination is specific, easy and inexpensive. It can be proposed for use in campaigns against goiters of nutritional origin.
在多哥两个位于地方性甲状腺肿流行区的地点（戈贝、莫雷坦）开展了一项试点研究。这项工作的目的是收集实验室和营养数据，以评估和跟踪针对碘缺乏的防治活动。对97份尿液样本进行了分析。我们使用优化的电位分析法研究了重要饮食物质（水和盐）的尿排泄和碘浓度。在多哥的这两个地点观察到的尿碘/肌酐比值（微克/克）的平均值，在戈贝分别为34.1±6.3，在莫雷坦为39.2±6.4。这些低值与在法国亚眠测定的生理值（147.5±56.3）有显著差异（P<10⁻⁹）。这两个地点的饮用水碘浓度较低（2微克/升）。与法国使用的加碘盐（11.2±0.2毫克/千克）相比，烹饪盐的碘浓度也较低（<0.2毫克/千克）。这些结果表明这两个地点都存在碘缺乏，可能是由于当地饮食中缺乏碘。碘测定具有特异性、简便且成本低廉。可建议将其用于营养性甲状腺肿的防治活动。
