Marks J L, Hair C S, Klock S C, Ginsburg B E, Pomerleau C S
University of Michigan, Department of Neurology, Ann Arbor 48109-0720.
J Subst Abuse. 1994;6(2):235-43. doi: 10.1016/s0899-3289(94)90265-8.
To investigate the possibility that cigarette smoking and other drug use are affected by menstrual phase in smokers with Late Luteal Phase Dysphoric Disorder (LLPDD), we examined daily diaries rating menstrual symptomatology, smoking, alcohol and nonprescription drug use, and caffeine intake in nine female smokers meeting criteria for LLPDD. Menstrual symptomatology peaked during the premenstrual phase. Smoking, alcohol, and nonprescription drug intake were increased during menses; caffeine intake was unaffected by phase. No systematic intrasubject correlation between symptomatology and smoking was detected. It was concluded that in women with LLPDD, smoking and alcohol and nonprescription drug intake appear to vary as a function of menstrual phase. The lack of intrasubject correlations between symptomatology and intake, and the failure of peak intake to coincide with peak symptomatology, however, indicate that these effects cannot be explained simply as "self-medication" of acute episodes of dysphoric mood.
为了研究患有晚黄体期烦躁障碍（LLPDD）的吸烟者中，吸烟及其他药物使用是否受月经周期影响，我们对符合LLPDD标准的九名女性吸烟者的日常日记进行了检查，这些日记记录了月经症状、吸烟、饮酒、非处方药使用及咖啡因摄入量。月经症状在经前期达到峰值。月经期间吸烟、饮酒及非处方药摄入量增加；咖啡因摄入量不受月经周期影响。未检测到症状与吸烟之间存在系统性的个体内相关性。研究得出结论，患有LLPDD的女性中，吸烟、饮酒及非处方药摄入量似乎随月经周期而变化。然而，症状与摄入量之间缺乏个体内相关性，且摄入量峰值与症状峰值未同时出现，这表明这些影响不能简单地解释为烦躁情绪急性发作时的“自我治疗”。
