血小板运输模型中漂移的估计形状函数。
An estimated shape function for drift in a platelet-transport model.
作者信息
Yeh C, Calvez A C, Eckstein E C
机构信息
Department of Biomedical Engineering, University of Miami, Coral Gables, Florida 33124.
出版信息
Biophys J. 1994 Sep;67(3):1252-9. doi: 10.1016/S0006-3495(94)80595-8.
Prior work has shown that concentration profiles of platelets in flowing whole blood and of platelet-sized beads in flowing blood suspensions can include near-wall excesses. A model to describe this phenomenon was built about a single-component convective diffusion equation. To incorporate redistribution to preferred sites by shear flows of red cell suspensions, the model used a drift shape function (in addition to the commonly used augmented diffusion coefficient). This paper reports experiments that provide an average concentration profile from which the shape function for that model is calculated; the experiments and shape function are for the particular conditions of 40% hematocrit, platelet-sized latex beads (2.5 microns diameter), tube ID of 217 microns, and a wall shear rate of 555 s-1. Less precise estimates of the shape function obtained from data of previous studies indicate that the shape function is similar for the hematocrit of 15%.
先前的研究表明，流动全血中血小板以及流动血液悬浮液中血小板大小珠子的浓度分布可能包括近壁过量。基于单组分对流扩散方程建立了一个描述此现象的模型。为了纳入红细胞悬浮液剪切流导致的向优选位点的重新分布，该模型使用了一个漂移形状函数（除了常用的增强扩散系数）。本文报告了一些实验，这些实验提供了一个平均浓度分布，据此计算该模型的形状函数；这些实验和形状函数针对的是血细胞比容为40%、血小板大小的乳胶珠（直径2.5微米）、管内径为217微米以及壁面剪切速率为555 s-1的特定条件。从先前研究的数据中获得的形状函数的不太精确估计表明，对于15%的血细胞比容，形状函数是相似的。
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