类风湿性恶病质中维生素B6状态异常。与自发性肿瘤坏死因子α产生及炎症标志物的关联。
Abnormal vitamin B6 status in rheumatoid cachexia. Association with spontaneous tumor necrosis factor alpha production and markers of inflammation.
作者信息
Roubenoff R, Roubenoff R A, Selhub J, Nadeau M R, Cannon J G, Freeman L M, Dinarello C A, Rosenberg I H
机构信息
Body Composition Laboratory, USDA HNRCA, Tufts University, Boston, MA 02111.
出版信息
Arthritis Rheum. 1995 Jan;38(1):105-9. doi: 10.1002/art.1780380116.
OBJECTIVE
To compare vitamin B6 levels in rheumatoid arthritis (RA) patients and healthy control subjects.
METHODS
We measured levels of vitamin B6 in 23 adults with well-controlled RA, and in 23 healthy control subjects matched for age, sex, race, and weight.
RESULTS
Although plasma folate and vitamin B12 concentrations and erythrocyte B6 activity coefficients were similar in the patients and controls, plasma levels of pyridoxal-5'-phosphate (PLP) were lower in the RA patient group (mean +/- SD 46.1 +/- 48.1 versus 69.3 +/- 58.4 nmoles/liter; P < 0.004). In multivariate analyses, PLP was inversely associated with tumor necrosis factor alpha (TNF alpha) production by peripheral blood mononuclear cells (PBMC) (P < 0.001), after adjustment for age, pain score, erythrocyte sedimentation rate, and use of nonsteroidal antiinflammatory drugs.
CONCLUSION
PLP levels are reduced in patients with RA. This reduction is associated with TNF alpha production by PBMC.
目的
比较类风湿关节炎（RA）患者与健康对照者体内维生素B6水平。
方法
我们检测了23例病情得到良好控制的成年RA患者以及23例年龄、性别、种族和体重相匹配的健康对照者的维生素B6水平。
结果
尽管患者和对照者的血浆叶酸、维生素B12浓度以及红细胞B6活性系数相似，但RA患者组的血浆磷酸吡哆醛（PLP）水平较低（平均值±标准差为46.1±48.1对69.3±58.4纳摩尔/升；P<0.004）。在多变量分析中，在校正年龄、疼痛评分、红细胞沉降率和非甾体抗炎药的使用情况后，PLP与外周血单核细胞（PBMC）产生的肿瘤坏死因子α（TNFα）呈负相关（P<0.001）。
结论
RA患者的PLP水平降低。这种降低与PBMC产生TNFα有关。
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