Simion F A, Rhein L D, Morrison B M, Scala D D, Salko D M, Kligman A M, Grove G L
Colgate-Palmolive Technology Center, Piscataway, New Jersey.
J Am Acad Dermatol. 1995 Feb;32(2 Pt 1):205-11. doi: 10.1016/0190-9622(95)90127-2.
Epidemiologic studies indicate that after using soaps and other personal care products, many consumers experience irritation. In 50% of the cases the feelings of skin dryness, itching, and stinging occur in the absence of visible signs of irritation.
We sought to determine the relation between self-perceived sensory responses of panelists to cleansing products and clinical signs of irritation.
A combination of exaggerated arm-washing methods was designed to induce clinical signs of irritation with psychometric techniques developed to quantify sensations.
Two studies demonstrated that panelists could reproducibly differentiate between products on the basis of the sensations they felt and that there was a significant correlation (frequently r > 0.80) between these and the observable signs. In the case of skin dryness panelists differentiated products several washing cycles before observable differences were detected.
Sensory evaluations of irritation yield additional information on soap and detergent irritancy beyond clinical observations and expand understanding of the irritation process.
流行病学研究表明，使用肥皂和其他个人护理产品后，许多消费者会出现刺激反应。在50%的案例中，皮肤干燥、瘙痒和刺痛感在没有明显刺激迹象的情况下出现。
我们试图确定小组成员对清洁产品的自我感觉的感官反应与刺激的临床体征之间的关系。
设计了一系列夸张的洗手方法，以诱导刺激的临床体征，并采用心理测量技术来量化感觉。
两项研究表明，小组成员能够根据他们感受到的感觉可重复地区分产品，并且这些感觉与可观察到的体征之间存在显著相关性（通常r>0.80）。在皮肤干燥的情况下，小组成员在检测到可观察到的差异之前的几个洗涤周期就能区分产品。
对刺激的感官评估除了临床观察之外，还能提供有关肥皂和洗涤剂刺激性的额外信息，并扩展了对刺激过程的理解。
