Koch P J, Franke W W
Dermatology Branch, National Cancer Institute, Bethesda, MD 20892.
Curr Opin Cell Biol. 1994 Oct;6(5):682-7. doi: 10.1016/0955-0674(94)90094-9.
The formation of supracellular structures, i.e. tissues and organs, is dependent on the spatially and temporally regulated formation of semistable cell-cell contacts. In recent years, the molecular components of such cell junctions, especially those occurring in epithelial cells, have been studied extensively, and the main proteins and glycoproteins of the 'adhering junctions' such as the desmosomes and the zonula adherens of polar epithelial cells have been characterized. We are now beginning to understand the complex protein-protein interactions that contribute to the assembly and disassembly of these structures and their roles in the attachment of specific filaments of the cytoskeleton.
超细胞结构（即组织和器官）的形成依赖于半稳定细胞间接触在空间和时间上的调控形成。近年来，此类细胞连接的分子成分，尤其是上皮细胞中的成分，已得到广泛研究，极性上皮细胞的“黏附连接”（如桥粒和黏着小带）的主要蛋白质和糖蛋白已被鉴定。我们现在开始理解促成这些结构组装和解聚的复杂蛋白质 - 蛋白质相互作用，以及它们在细胞骨架特定细丝附着中的作用。
