Demirbilek S, Bernay F, Rizalar R, Bariş S, Gürses N
Department of Pediatric Surgery, Ondokuz Mayis University, Children's Hospital, Samsun, Turkey.
J Pediatr Surg. 1994 Nov;29(11):1425-8. doi: 10.1016/0022-3468(94)90136-8.
The effects of sex hormones on the synthesis of collagen were investigated in rats with alkali-induced corrosive esophageal burns. In 75 rats, a standard esophageal burn was produced as described by Gehanno. The animals were then grouped as follows: controls (group A), animals with pure esophageal burns (group B), and animals with esophageal burns treated with estradiol and progesterone (group C). All animals were killed on the 28th day of the experiment. Hydroxyproline levels were determined, and histopathologic evaluation was performed for each group. The hydroxyproline levels were significantly lower in the rats treated with estradiol and progesterone. Histopathologically, collagen deposition in the submucosa and tunica muscularis was lower in the estradiol/progesterone group than in the group with pure esophageal burns. Based on the results, the authors believe that estradiol and progesterone inhibited new collagen synthesis, and therefore, alkali-induced esophageal stricture formation.
在碱诱导的腐蚀性食管烧伤大鼠中研究了性激素对胶原蛋白合成的影响。按照Gehanno所述方法，对75只大鼠造成标准的食管烧伤。然后将动物分为以下几组：对照组（A组）、单纯食管烧伤动物组（B组）以及用雌二醇和孕酮治疗的食管烧伤动物组（C组）。所有动物在实验第28天处死。测定羟脯氨酸水平，并对每组进行组织病理学评估。用雌二醇和孕酮治疗的大鼠中羟脯氨酸水平显著较低。组织病理学上，雌二醇/孕酮组黏膜下层和肌层的胶原蛋白沉积低于单纯食管烧伤组。基于这些结果，作者认为雌二醇和孕酮抑制了新胶原蛋白的合成，因此也抑制了碱诱导的食管狭窄形成。
