Senturk Ekrem, Sen Serdar, Pabuccu Engin, Unsal Cengiz, Meteoglu Ibrahim
Thoracic Surgery Department, Medicine Faculty, Adnan Menderes University, 09010, Aydin, Turkey.
Pediatr Surg Int. 2010 Mar;26(3):257-61. doi: 10.1007/s00383-009-2546-0. Epub 2009 Dec 11.
Caustic esophagitis is a serious clinical problem and many agents are currently tried out in many experimental models. The model of Gehanno is the most commonly used invasive model, which is required general anesthesia and laparotomy. We aimed to form a new pratic and non-invasive model.
Twenty rats were studied. The stomachs of the rats were reached through guidance catheter with ether anesthesia, Fogarty catheter was send in through, it was filled with pressure in the stomach. Then, Fogarty was pulled back and stomach entrance was closed. Control group was given; n = 10; 0.25 cc isotonic, injury group was given; n = 10; 0.25 cc, %40 NaOH and it was waited for 60 s. Their esophagi were examined after 28 days.
In the histopathologic evaluation of the control group, no pathology was discovered. Sub-mucosal collagen increase, muscularis mucosa and tunica muscularis damage have all been detected in the injury group p < 0.005; p < 0.003; p < 0.005).
Corrosive esophagitis was formed without general anesthesia and laparotomy. Burn was formed in the total esophagus, unlike other models in which the burn is just formed at the below end. With our less invasive, more easily applied model; treatment agents can be given just as the corrosive esophagitis can be formed.
腐蚀性食管炎是一个严重的临床问题，目前许多药物正在多种实验模型中进行试验。Gehanno模型是最常用的侵入性模型，需要全身麻醉和开腹手术。我们旨在建立一种新的实用且非侵入性的模型。
对20只大鼠进行研究。在乙醚麻醉下通过引导导管到达大鼠胃部，将Fogarty导管送入，在胃内充压。然后，将Fogarty导管撤回并封闭胃入口。对照组给予；n = 10；0.25 cc等渗液，损伤组给予；n = 10；0.25 cc，40%氢氧化钠，并等待60秒。28天后检查它们的食管。
在对照组的组织病理学评估中，未发现病理改变。在损伤组中检测到粘膜下胶原增加、粘膜肌层和肌层损伤（p < 0.005；p < 0.003；p < 0.005）。
无需全身麻醉和开腹手术即可形成腐蚀性食管炎。与其他仅在食管下端形成烧伤的模型不同，本模型在整个食管形成烧伤。通过我们这种侵入性较小、更易于应用的模型；可以在形成腐蚀性食管炎时给予治疗药物。
