Chalmers W S, Baxendale W
Vet Rec. 1994 Oct 8;135(15):349-53. doi: 10.1136/vr.135.15.349.
Two groups of six-week-old beagle puppies were vaccinated with either high titre canine distemper virus or human measles virus, a third group remaining unvaccinated. All the puppies were subsequently challenged by the nasopharyngeal route at 10 weeks old with the virulent Snyder-Hill strain of canine distemper. Severe clinical signs were observed in 90 per cent of the unvaccinated dogs but both groups of vaccinated dogs survived the challenge. High temperatures were recorded in 20 per cent of the measles vaccinates and abdominal petechial rashes were observed in 60 per cent of them. The only clinical signs observed in the puppies vaccinated with distemper virus were transient rashes in 20 per cent of the group. The high titre canine distemper vaccine stimulated a humoral response quickly in 78 per cent of the puppies in the presence of maternally derived antibody and protected them against challenge with the virulent Snyder-Hill strain of distemper virus. The remaining dogs responded sluggishly but were still protected against challenge. The results of field surveys showed that 95 per cent of young puppies with different levels of maternally derived antibodies responded to the distemper component in a vaccine also containing canine parvovirus. No incompatibility was observed between the two components.
将两组六周大的比格幼犬分别用高滴度犬瘟热病毒或人麻疹病毒进行疫苗接种，第三组不接种。随后，所有幼犬在10周龄时通过鼻咽途径用犬瘟热强毒株斯奈德 - 希尔株进行攻毒。未接种疫苗的犬中有90%出现严重临床症状，但两组接种疫苗的犬在攻毒后均存活。接种麻疹疫苗的犬中有20%体温升高，60%出现腹部瘀点疹。接种犬瘟热病毒的幼犬中观察到的唯一临床症状是该组20%的幼犬出现短暂皮疹。高滴度犬瘟热疫苗在存在母源抗体的情况下，能使78%的幼犬迅速产生体液免疫反应，并保护它们免受犬瘟热病毒强毒株斯奈德 - 希尔株的攻毒。其余犬的反应较慢，但仍受到攻毒保护。现场调查结果显示，95%具有不同水平母源抗体的幼犬对同时含有犬细小病毒的疫苗中的犬瘟热成分有反应。未观察到两种成分之间存在不相容性。
