II型“诱饵”受体：白细胞介素1的一种新型调节途径。
The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1.
作者信息
Colotta F, Dower S K, Sims J E, Mantovani A
机构信息
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
出版信息
Immunol Today. 1994 Dec;15(12):562-6. doi: 10.1016/0167-5699(94)90217-8.
PMID:7848516
Abstract
The interleukin 1 (IL-1) system plays a central role in inflammation and immunity. Of the two receptors that bind IL-1, the type I receptor is known to mediate signaling activity, whereas the function of the type II receptor remains unknown. Here, Francesco Colotta and colleagues review the properties of these receptors and summarize evidence indicating that the type II receptor acts as a regulated decoy target for IL-1.
摘要
白细胞介素1（IL-1）系统在炎症和免疫中起核心作用。在与IL-1结合的两种受体中，已知I型受体介导信号传导活性，而II型受体的功能仍然未知。在这里，弗朗切斯科·科洛塔及其同事回顾了这些受体的特性，并总结了表明II型受体作为IL-1的调节性诱饵靶点的证据。
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