James C B
Division of Pharmacological Sciences and Toxicology, United Medical School of Guy's Hospital, London.
Br J Ophthalmol. 1994 Nov;78(11):818-22. doi: 10.1136/bjo.78.11.818.
Trabeculectomy, despite producing an effective reduction in intraocular pressure, may not prevent continued visual field loss. This may be because of the presence of other factors in the pathogenesis of glaucoma. Vascular factors have been suggested as being particularly important. To study the effect of trabeculectomy on ocular blood flow the technique of ocular pulse analysis has been used to derive a measure of pulsatile ocular blood flow in 17 patients (average age 65.6 (SD 1.8) years) undergoing trabeculectomy. A significant increase in pulsatile ocular blood flow of 29% was observed in the group as a whole in the standing position following operation but in some individuals blood flow changed only slightly despite a large reduction in intraocular pressure. The significance of these findings in relation to the prognosis of visual field preservation following trabeculectomy is discussed.
小梁切除术尽管能有效降低眼压，但可能无法阻止视野的持续丧失。这可能是因为青光眼发病机制中存在其他因素。血管因素被认为尤为重要。为了研究小梁切除术对眼血流的影响，采用眼脉搏分析技术对17例接受小梁切除术的患者（平均年龄65.6（标准差1.8）岁）的搏动性眼血流进行了测量。术后站立位时，整个组的搏动性眼血流显著增加了29%，但在一些个体中，尽管眼压大幅降低，血流变化却很小。讨论了这些发现与小梁切除术后视野保留预后的相关性。
