与摄入乙醇相关的甲氟喹不良反应。
Adverse reaction to mefloquine associated with ethanol ingestion.
作者信息
Wittes R C, Saginur R
机构信息
Division of Infectious Disease, Ottawa Civic Hospital, Ont.
出版信息
CMAJ. 1995 Feb 15;152(4):515-7.
Abstract
A 40-year-old man with no history of neuropsychiatric illness was taking one 250-mg tablet of mefloquine (MFQ) weekly for malaria prophylaxis while in Tanzania. He experienced no adverse reaction in association with his first two doses. Concurrently with both his third and his fourth dose he consumed about half a litre of whisky. On both occasions he experienced hallucinations, paranoid delusions and suicidal ideation. Thereafter he continued taking the MFQ, abstained completely from ethanol ingestion and had no recurrence of psychiatric symptoms. It is hypothesized that the combination of MFQ and ethanol caused the two episodes of severe psychiatric disturbance.
摘要
一名40岁无神经精神疾病史的男子在坦桑尼亚期间，每周服用一片250毫克的甲氟喹（MFQ）预防疟疾。他在前两剂服用期间未出现不良反应。在第三剂和第四剂服用时，他同时饮用了约半升威士忌。两次他都出现了幻觉、偏执妄想和自杀念头。此后，他继续服用甲氟喹，完全戒酒，精神症状未再复发。据推测，甲氟喹和乙醇的联用导致了这两起严重精神障碍发作。
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本文引用的文献
1
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Trop Med Parasitol. 1993 Sep;44(3):257-65.
2
Mefloquine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic efficacy.甲氟喹：其抗疟活性、药代动力学特性及治疗效果综述
Drugs. 1993 Mar;45(3):430-75. doi: 10.2165/00003495-199345030-00009.
3
Neurologic reactions after a therapeutic dose of mefloquine.治疗剂量的甲氟喹后的神经反应。
N Engl J Med. 1989 Nov 16;321(20):1415-6. doi: 10.1056/NEJM198911163212017.
4
Acute psychosis after mefloquine.甲氟喹致急性精神病
Lancet. 1989 Jul 29;2(8657):282. doi: 10.1016/s0140-6736(89)90474-1.
5
Malaria chemoprophylaxis among European tourists in tropical Africa: use, adverse reactions, and efficacy.热带非洲地区欧洲游客的疟疾化学预防：使用情况、不良反应及疗效。
Bull World Health Organ. 1990;68(3):313-22.
6
Neuropsychiatric side effects of mefloquine.甲氟喹的神经精神副作用。
N Engl J Med. 1990 Jun 14;322(24):1752-3. doi: 10.1056/nejm199006143222416.
7
Neuropsychiatric side effects after the use of mefloquine.
Am J Trop Med Hyg. 1991 Jul;45(1):86-91. doi: 10.4269/ajtmh.1991.45.86.
8
Mefloquine prophylaxis: an overview of spontaneous reports of severe psychiatric reactions and convulsions.甲氟喹预防：严重精神反应和惊厥自发报告概述
J Trop Med Hyg. 1992 Jun;95(3):167-79.
9
Kinetics of a new antimalarial, mefloquine.新型抗疟药甲氟喹的动力学
Clin Pharmacol Ther. 1979 Sep;26(3):372-9. doi: 10.1002/cpt1979263372.
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