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肾脏保存方法(作者译)

[Kidney preservation methods (author's transl)].

作者信息

Michielsen P, Oei L S, Roels L

出版信息

Ateneo Parmense Acta Biomed. 1975 Sep-Oct;46(5):387-400.

PMID:786320
Abstract

The results of preservation of the two kidneys of the same animal by two different techniques and then reimplanted on the same femoral artery, have been compared. The two methods are the following: 1) Short starting perfusion by Collins solution and than cold storage a 4 degrees C in the same solution. 2) Continuous perfusion by machine supplied by pulsatile pump, oxigenator, cooling. The first more impressive result by using continuous perfusion is the possibility of nullifying the effects of warm ischemia up to 30'. Kidney preservation with continuous perfusion is like to give less problems in the postoperatory period. Some weeks after transplantation however, the problems seems to increase in comparison with kidneys stored in Collins solution and not rarely sudden GFR decreases or anurias without immunologic rejection has been observed. Cautious conclusion should advise to use Collins solution when there has not been a long warm ischemia.

摘要

对同一动物的两个肾脏采用两种不同技术进行保存,然后再植入同一条股动脉,并对结果进行了比较。两种方法如下:1)先用柯林斯溶液进行短时间起始灌注,然后在4℃下于同一溶液中冷藏。2)通过配备脉动泵、氧合器和冷却装置的机器进行持续灌注。使用持续灌注的第一个更显著的结果是,有可能消除长达30分钟的热缺血影响。持续灌注保存肾脏在术后似乎问题较少。然而,移植几周后,与保存在柯林斯溶液中的肾脏相比,问题似乎增多了,并且经常观察到肾小球滤过率突然下降或无免疫排斥反应的无尿症。谨慎的结论是,在没有长时间热缺血的情况下,建议使用柯林斯溶液。

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