采用脉冲场凝胶电泳分析苏格兰结核分枝杆菌复合群的群体遗传学。
Population genetics of Mycobacterium tuberculosis complex in Scotland analysed by pulsed-field gel electrophoresis.
作者信息
Olson E S, Forbes K J, Watt B, Pennington T H
机构信息
Department of Medical Microbiology, University of Aberdeen.
出版信息
Epidemiol Infect. 1995 Feb;114(1):153-60. doi: 10.1017/s0950268800052006.
The results of typing of 121 strains in the Mycobacterium tuberculosis complex by PFGE are presented. Every isolate from patients in Scotland over a 3-month period for M. tuberculosis and for 1 year for M. bovis were included along with several laboratory strains including those of BCG. The PFGE results suggest that the population structure of all the strains in this complex is distinctly simple with limited genetic diversity and also suggest that M. bovis is not a distinct species.
本文展示了通过脉冲场凝胶电泳（PFGE）对121株结核分枝杆菌复合群菌株进行分型的结果。研究纳入了苏格兰患者在3个月内分离出的所有结核分枝杆菌菌株以及1年内分离出的所有牛分枝杆菌菌株，同时还包括了几种实验室菌株，其中有卡介苗（BCG）菌株。PFGE结果表明，该复合群中所有菌株的群体结构明显单一，遗传多样性有限，这也表明牛分枝杆菌并非一个独特的物种。
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