Nakamura R M, Bylund D J
Department of Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037.
J Clin Lab Anal. 1994;8(6):347-59. doi: 10.1002/jcla.1860080604.
Systemic lupus erythematosus (SLE) is a nonorgan-specific autoimmune disease which affects multiple organ systems and is multifactorial in etiology. SLE is the prototypic systemic rheumatic disease with immune dysregulation characterized by (1) polyclonal activation of B-cells and (2) production of a large spectrum of autoantibodies with a marked preference for nuclear and intracellular antigens. The clinical and laboratory manifestations and criteria for classification and diagnosis of systemic lupus erythematosus, lupus-like syndromes, and various subsets of systemic lupus erythematosus, are reviewed. The differential diagnosis of SLE and related diseases is described with correlation of specific intracellular autoantibodies.
系统性红斑狼疮（SLE）是一种非器官特异性自身免疫性疾病，可累及多个器官系统，病因是多因素的。SLE是免疫失调的典型系统性风湿性疾病，其特征为：（1）B细胞多克隆激活；（2）产生大量自身抗体，且明显偏向于核抗原和细胞内抗原。本文综述了系统性红斑狼疮、狼疮样综合征及系统性红斑狼疮各亚型的临床表现、实验室检查结果以及分类和诊断标准。文中还描述了SLE与相关疾病的鉴别诊断，并将其与特定的细胞内自身抗体进行了关联。
