Specker C, Becker A, Lakomek H J, Bach D, Grabensee B
Abteilung für Endokrinologie und Rheumatologie, Heinrich Heine-Universität Düsseldorf.
Z Rheumatol. 1994 Nov-Dec;53(6):339-45.
A retrospective analysis of 21 male and 82 female patients with systemic lupus erythematosus (SLE) was performed in order to identify sex-linked differences in disease manifestations. As organ manifestation, cardiac involvement was assessed in 12 of 21 male patients (57%) and in 18 of 82 females (22%; p < 0.05). Renal involvement occurred in 16 male (76%) vs 26 female patients (32%; p < 0.05). Endstage renal disease developed in 5 of the 21 men (24%), but only in 6 of the 82 women (7%) with SLE. The most striking clinical result was the high frequency of thrombembolic complications in male SLE-patients. Twelve out of 21 males (57%) experienced more than 30 thrombembolic events in contrast to 9 events in 5 out of 82 females (6%; p < 0.0001). Persisting elevated IgG-anti-cardiolipin antibodies were found in 48% of male and only 16% of female patients (p < 0.05). In conclusion, these data suggest that SLE in males is characterized by more frequent and severe organ involvement and especially by striking prevalence of partly life-threatening thrombembolic complications.
为了确定系统性红斑狼疮（SLE）在疾病表现方面的性别差异，对21例男性和82例女性SLE患者进行了回顾性分析。作为器官表现，21例男性患者中有12例（57%）出现心脏受累，82例女性患者中有18例（22%）出现心脏受累（p<0.05）。16例男性（76%）出现肾脏受累，而26例女性患者（32%）出现肾脏受累（p<0.05）。21例男性中有5例（24%）发展为终末期肾病，而82例女性SLE患者中只有6例（7%）发展为终末期肾病。最显著的临床结果是男性SLE患者血栓栓塞并发症的发生率很高。21例男性中有12例（57%）经历了30多次血栓栓塞事件，相比之下，82例女性中有5例（6%）经历了9次血栓栓塞事件（p<0.0001）。48%的男性患者存在持续升高的IgG抗心磷脂抗体，而女性患者中只有16%存在该抗体（p<0.05）。总之，这些数据表明，男性SLE的特点是器官受累更频繁、更严重，尤其是部分危及生命的血栓栓塞并发症的发生率显著较高。
