Williamson T H, Lowe G D, Baxter G M
Tennent Institute of Ophthalmology, Glasgow.
Br J Ophthalmol. 1995 Jan;79(1):17-22. doi: 10.1136/bjo.79.1.17.
The influence of multiple systemic factors upon the blood velocities obtained from the orbital circulations was investigated. The velocities obtained by colour Doppler imaging from the ophthalmic artery, central retinal artery, and vein from 95 ophthalmologically healthy volunteers were analyzed. The effects of age, systemic blood pressure, and smoking habit were examined. In 24 volunteers blood viscosity was also measured and its relation with blood velocity assessed. Age was weakly negatively correlated with the blood velocities in the ophthalmic artery and weakly positively correlated with resistance to flow in the retinal circulation. Systolic blood pressure showed a positive correlation with the peak systolic velocities in the arteries while cigarette smoking was associated with lower ophthalmic artery velocities. Increased haematocrit and viscosity were positively correlated with resistance to flow proximal to the ophthalmic artery and red cell rigidity negatively correlated with the pulsatility of flow in the retinal vein. These results help to identify the roles of systemic conditions in the ocular circulation. The influence of blood viscosity on retinal venous flow may be relevant to the pathogenetic mechanisms of conditions such as central retinal vein occlusion.
研究了多种全身因素对从眼眶循环获得的血流速度的影响。分析了95名眼科健康志愿者通过彩色多普勒成像获得的眼动脉、视网膜中央动脉和静脉的血流速度。研究了年龄、全身血压和吸烟习惯的影响。对24名志愿者还测量了血液粘度，并评估了其与血流速度的关系。年龄与眼动脉血流速度呈弱负相关，与视网膜循环中的血流阻力呈弱正相关。收缩压与动脉收缩期峰值速度呈正相关，而吸烟与眼动脉血流速度较低有关。血细胞比容增加和粘度升高与眼动脉近端的血流阻力呈正相关，红细胞刚性与视网膜静脉血流的搏动性呈负相关。这些结果有助于确定全身状况在眼循环中的作用。血液粘度对视网膜静脉血流的影响可能与视网膜中央静脉阻塞等疾病的发病机制有关。
