Adams J N, Jamieson M, Rawles J M, Trent R J, Jennings K P
Cardiac Department, Aberdeen Royal Infirmary, Foresterhill.
Br Heart J. 1995 Jan;73(1):87-91. doi: 10.1136/hrt.73.1.87.
To determine whether women with myocardial infarction are treated differently from men of the same age and to assess the effect of changes in the coronary care unit admission policy.
Clinical audit.
The coronary care unit and general medical wards of a teaching hospital. In 1990 the age limit for admission to coronary care was 65 years. This age limit was removed in 1991.
539 female and 977 male patients admitted with myocardial infarction between 1990 and 1992.
Admission to the coronary care unit, administration of thrombolysis, and in-hospital mortality.
409 men and 254 women were admitted with myocardial infarction in 1990 and 568 men and 285 women in 1992. Removal of the age limit for admission to the coronary care unit resulted in an increase in the numbers of both sexes admitted with myocardial infarction. In both years, however, proportionately more men with infarction were admitted to coronary care: 226 men (55%) and 96 women (38%) (P < 0.01) (95% CI 7 to 28) in 1990 and 459 men (81%) and 200 women (70%) (P < 0.01) (%CI 2 to 19) in 1992. Some 246 men (60%) and 133 women (52%) with infarction (P < 0.01) received thrombolytic treatment in 1990 compared with 319 men (56%) and 130 women (46%) (P < 0.01) in 1992. The mean age of women sustaining a myocardial infarction was significantly greater in both years studied. In 1992 a total of 78 men (7%) and 34 women (4%) (P < 0.05) admitted with chest pain underwent cardiac catheterisation before discharge from hospital.
Differences in admission rates to the coronary care unit and the rate of thrombolysis between the sexes can be explained by the older age of women sustaining infarction. The application of age limits for admission to coronary care or administration of thrombolysis places elderly patients at a disadvantage. As women sustain myocardial infarctions at an older age they are placed at a greater disadvantage.
确定心肌梗死女性患者与同龄男性患者的治疗方式是否不同,并评估冠心病监护病房收治政策变化的影响。
临床审计。
一家教学医院的冠心病监护病房和普通内科病房。1990年冠心病监护病房的收治年龄上限为65岁。该年龄限制于1991年取消。
1990年至1992年间收治的539例心肌梗死女性患者和977例男性患者。
入住冠心病监护病房、进行溶栓治疗以及院内死亡率。
1990年有409例男性和254例女性因心肌梗死入院,1992年有568例男性和285例女性入院。取消冠心病监护病房的收治年龄限制后,因心肌梗死入院的男女患者数量均有所增加。然而,在这两年中,因梗死入院的男性患者进入冠心病监护病房的比例都更高:1990年为226例男性(55%)和96例女性(38%)(P<0.01)(95%可信区间7至28),1992年为459例男性(81%)和200例女性(70%)(P<0.01)(可信区间2至19)。1990年约246例男性(60%)和133例女性(52%)(P<0.01)接受了溶栓治疗,而1992年为319例男性(56%)和130例女性(46%)(P<0.01)。在研究的两年中,发生心肌梗死的女性的平均年龄均显著更大。1992年,共有78例男性(7%)和34例女性(4%)(P<0.05)因胸痛入院,在出院前接受了心导管检查。
冠心病监护病房收治率和溶栓率的性别差异可由发生梗死的女性年龄较大来解释。对冠心病监护病房收治或溶栓治疗设置年龄限制会使老年患者处于不利地位。由于女性发生心肌梗死的年龄较大,她们处于更大的不利地位。