Mrozikiewicz A, Kiełczewska-Mrozikiewicz D, Lowicki Z, Chmara E, Korzeniowska K, Mrozikiewicz P M
Department of Clinical Pharmacology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
Acta Diabetol. 1994 Dec;31(4):236-7. doi: 10.1007/BF00571958.
Alloxan is a well-known and universally used agent for evoking experimental diabetes through its toxic effect on the B cells of the Langerhans islets. In our study, blood levels of alloxan in children with insulin-dependent diabetes mellitus were investigated. The observations were made in 68 children aged 6-15 years and in a control group of 44 healthy children in the same age range. Alloxan levels were estimated spectrophotometrically. The mean level of alloxan in blood from children with insulin-dependent diabetes mellitus was 8.76 +/- 9.64 micrograms/ml and in blood from healthy children was 1.53 +/- 1.10 micrograms/ml. The difference was statistically significant (P < 0.05). The metabolism of alloxan leads to the production of free superoxide radicals which, as is well known, injure cells and cause conditions conducive to the occurrence of diseases from autoimmunity. The results obtained suggest therefore that higher levels of alloxan in diabetic children are of significance in the onset of insulin-dependent diabetes mellitus.
四氧嘧啶是一种广为人知且被普遍使用的药物，它通过对胰岛β细胞产生毒性作用来诱发实验性糖尿病。在我们的研究中，对胰岛素依赖型糖尿病患儿的血液中四氧嘧啶水平进行了调查。观察对象为68名6至15岁的儿童以及44名同年龄段的健康儿童组成的对照组。采用分光光度法估算四氧嘧啶水平。胰岛素依赖型糖尿病患儿血液中四氧嘧啶的平均水平为8.76±9.64微克/毫升，健康儿童血液中的平均水平为1.53±1.10微克/毫升。差异具有统计学意义（P<0.05）。四氧嘧啶的代谢会导致产生游离超氧自由基，众所周知，这些自由基会损伤细胞并引发有利于自身免疫性疾病发生的条件。因此，所获得的结果表明，糖尿病患儿中较高水平的四氧嘧啶在胰岛素依赖型糖尿病的发病中具有重要意义。
