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1
Immune potential in human uraemia. 1. Relationship of glomerular filtration rate to depression of immune potential.人类尿毒症中的免疫潜能。1. 肾小球滤过率与免疫潜能降低的关系。
J Clin Pathol. 1976 Sep;29(9):765-9. doi: 10.1136/jcp.29.9.765.
2
Immune potential in human uraemia. 2. Changes after regular haemodialysis therapy.人类尿毒症中的免疫潜能。2. 规律血液透析治疗后的变化。
J Clin Pathol. 1976 Sep;29(9):770-2. doi: 10.1136/jcp.29.9.770.
3
Immune responses in uremia.尿毒症中的免疫反应。
Clin Nephrol. 1973 Nov-Dec;1(6):351-60.
4
Cellular immunity in renal failure: depression of lymphocyte transformation by uraemia and methylprednisolone. Intra-individual consistency of lymphocyte responses to the in vitro suppressive effect of steroid.
Int Arch Allergy Appl Immunol. 1984;74(3):241-5. doi: 10.1159/000233551.
5
Sulphamethoxazole-trimethoprim: effect on antibody response in man.
Chemotherapy. 1976;22(1):37-42. doi: 10.1159/000221908.
6
Lymphocyte transformation in human plasma without addition of synthetic medium. A study of immune function in patients with chronic uraemia or diabetes mellitus.不添加合成培养基的人血浆中的淋巴细胞转化。对慢性尿毒症或糖尿病患者免疫功能的研究。
Int Arch Allergy Appl Immunol. 1976;51(6):732-41. doi: 10.1159/000231651.
7
[Humoral and cellular immunity in uremia].[尿毒症中的体液免疫和细胞免疫]
Mikrobiyol Bul. 1982 Jul;16(3):191-5.
8
[Kinetics of tetanus antitoxin after administration of specific immunoglobulins].[特异性免疫球蛋白给药后破伤风抗毒素的动力学]
Boll Ist Sieroter Milan. 1980 Nov 30;59(5):493-7.
9
Host immune status in uraemia. I. Cell-mediated immune mechanisms.尿毒症患者的宿主免疫状态。I. 细胞介导的免疫机制。
Clin Exp Immunol. 1980 Jul;41(1):115-22.
10
[Immunostaging (author's transl)].免疫分期（作者译）
Zentralbl Chir. 1978;103(11):689-705.

引用本文的文献

1
Studies on IL-2 production and T-cell colony forming unit in patients with chronic renal failure.慢性肾衰竭患者白细胞介素-2产生及T细胞集落形成单位的研究
Korean J Intern Med. 1993 Jul;8(2):86-92. doi: 10.3904/kjim.1993.8.2.86.
2
Effect of uremia on lymphocyte transformation and chemiluminescence by spleen cells of normal and Cryptococcus neoformans-infected mice.尿毒症对正常及新型隐球菌感染小鼠脾脏细胞淋巴细胞转化和化学发光的影响。
Infect Immun. 1981 Jun;32(3):1073-8. doi: 10.1128/iai.32.3.1073-1078.1981.
3
Immunomodulating properties of the uremic pentapeptide H-Asp-Leu-Trp-Glu-Lys-OH in vitro.尿毒症五肽H-天冬氨酸-亮氨酸-色氨酸-谷氨酸-赖氨酸-OH的体外免疫调节特性
Klin Wochenschr. 1986 Jul 15;64(14):642-7. doi: 10.1007/BF01726916.
4
The effect of maintenance dialysis on lymphocyte function. I. Haemodialysis.维持性透析对淋巴细胞功能的影响。I. 血液透析
Clin Exp Immunol. 1978 Jul;33(1):95-101.
5
Mechanisms in secondary hypogammaglobulinaemia.继发性低丙种球蛋白血症的机制。
J Clin Pathol Suppl (R Coll Pathol). 1979;13:15-22. doi: 10.1136/jcp.s3-13.1.15.
6
Humoral inhibitors of the immune response in uremia. II. Further characterization of an immunosuppressive factor in uremic serum.尿毒症中免疫反应的体液抑制剂。II. 尿毒症血清中一种免疫抑制因子的进一步特性分析。
Am J Pathol. 1979 Nov;97(2):277-90.

本文引用的文献

1
Production of antibody in patients with uremia.尿毒症患者抗体的产生。
N Engl J Med. 1958 Aug 14;259(7):320-3. doi: 10.1056/NEJM195808142590703.
2
Tetanus antitoxin titration by haemagglutination.通过血凝反应进行破伤风抗毒素滴定
J Hyg (Lond). 1957 Sep;55(3):382-401. doi: 10.1017/s0022172400037293.
3
Prolonged survival of skin homografts in uremic patients.尿毒症患者皮肤同种异体移植的长期存活
Ann N Y Acad Sci. 1957 Mar 22;64(5):967-76. doi: 10.1111/j.1749-6632.1957.tb52488.x.
4
The effect of severe battle injury and of post-traumatic renal failure on resistance to infection.严重战伤及创伤后肾衰竭对抗感染能力的影响。
Ann Surg. 1955 Aug;142(2):145-63. doi: 10.1097/00000658-195508000-00001.
5
Response of human blood lymphocytes to tuberculin PPD in tissue culture.人血淋巴细胞在组织培养中对结核菌素纯蛋白衍生物的反应。
Immunology. 1967 Apr;12(4):417-29.
6
In vitro reactivity of human lymphocytes in uraemia--a comparison with the impairment of delayed hypersensitivity.尿毒症患者人类淋巴细胞的体外反应性——与迟发型超敏反应损伤的比较。
Clin Exp Immunol. 1969 Jul;5(1):75-82.
7
The immunopathological significance of the heterogeneity of antibody affinity.抗体亲和力异质性的免疫病理学意义。
Clin Exp Immunol. 1971 Aug;9(2):193-9.
8
Immunochemical quantitation of antigens by single radial immunodiffusion.通过单向辐射免疫扩散法对抗原进行免疫化学定量。
Immunochemistry. 1965 Sep;2(3):235-54. doi: 10.1016/0019-2791(65)90004-2.
9
The conversion phenomenon of uremic lymphocytes: mechanisms of nucleic acid kinetics.尿毒症淋巴细胞的转化现象：核酸动力学机制
J Reticuloendothel Soc. 1971 May;9(5):409-23.
10
In vitro reactivity of human lymphocytes in chronic uraemia: analysis and interpretation.慢性尿毒症患者人类淋巴细胞的体外反应性：分析与解读
Clin Exp Immunol. 1971 Feb;8(2):213-27.

人类尿毒症中的免疫潜能。1. 肾小球滤过率与免疫潜能降低的关系。

Immune potential in human uraemia. 1. Relationship of glomerular filtration rate to depression of immune potential.

作者信息

Byron P R, Mallick N P, Taylor G

出版信息

J Clin Pathol. 1976 Sep;29(9):765-9. doi: 10.1136/jcp.29.9.765.

DOI:10.1136/jcp.29.9.765
PMID:789407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC476175/
Abstract

Aspects of immune potential in uraemic subjects, categorized by glomerular filtration rate, were intercompared and compared with results obtained from a group of normal volunteers. Evidence is presented to show that depression of both cellular and humoral immune potential occurs with progressive reduction of glomerular filtration rate. Lymphocyte transformation testing to the non-specific mitogen PHA revealed a significant elevation of blastogenic response in uraemia after 96 hours of incubation.

摘要

根据肾小球滤过率对尿毒症患者的免疫潜能进行分类，相互比较并与一组正常志愿者的结果进行比较。有证据表明，随着肾小球滤过率的逐渐降低，细胞免疫和体液免疫潜能均会受到抑制。对非特异性有丝分裂原PHA的淋巴细胞转化试验显示，在培养96小时后，尿毒症患者的母细胞化反应显著升高。