人类尿毒症中的免疫潜能。1. 肾小球滤过率与免疫潜能降低的关系。
Immune potential in human uraemia. 1. Relationship of glomerular filtration rate to depression of immune potential.
作者信息
Byron P R, Mallick N P, Taylor G
出版信息
J Clin Pathol. 1976 Sep;29(9):765-9. doi: 10.1136/jcp.29.9.765.
Abstract
Aspects of immune potential in uraemic subjects, categorized by glomerular filtration rate, were intercompared and compared with results obtained from a group of normal volunteers. Evidence is presented to show that depression of both cellular and humoral immune potential occurs with progressive reduction of glomerular filtration rate. Lymphocyte transformation testing to the non-specific mitogen PHA revealed a significant elevation of blastogenic response in uraemia after 96 hours of incubation.
摘要
根据肾小球滤过率对尿毒症患者的免疫潜能进行分类，相互比较并与一组正常志愿者的结果进行比较。有证据表明，随着肾小球滤过率的逐渐降低，细胞免疫和体液免疫潜能均会受到抑制。对非特异性有丝分裂原PHA的淋巴细胞转化试验显示，在培养96小时后，尿毒症患者的母细胞化反应显著升高。
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