Braun D, Pauli N, Séquin U, Zähner H
Universität Tübingen, Germany.
FEMS Microbiol Lett. 1995 Feb 1;126(1):37-42. doi: 10.1111/j.1574-6968.1995.tb07387.x.
Streptomyces antibioticus strain TU 99, from which a wide variety of active compounds had been isolated previously, was reinvestigated using an HPLC photoconductivity screening system. Four new compounds were isolated, characterized and their constitutions determined. All four were alpha, beta-unsaturated gamma-lactones; the most abundant compound 3 (C10H16O4), as well as compound 1 (C9H14O4) had a hydroxy group at C(5) of the lactone ring. The four lactones showed antibiotic activity against Pseudomonas aeruginosa and also a weak inhibition of the chitinase from Serratia marcescens.
先前已从抗生链霉菌TU 99菌株中分离出多种活性化合物，现使用高效液相色谱光电导筛选系统对其进行重新研究。分离并鉴定了四种新化合物，并确定了它们的结构。这四种化合物均为α，β-不饱和γ-内酯；含量最高的化合物3（C10H16O4）以及化合物1（C9H14O4）在内酯环的C(5)处有一个羟基。这四种内酯对铜绿假单胞菌具有抗菌活性，并且对粘质沙雷氏菌的几丁质酶也有微弱的抑制作用。
