系统性红斑狼疮伴狼疮细胞及抗核因子阴性
Systemic lupus erythematosus with negative LE cells and antinuclear factor.
作者信息
Gladman D D, Chalmers A, Urowitz M B
出版信息
J Rheumatol. 1978 Summer;5(2):142-7.
PMID:78982
Abstract
In the course of a prospective study of 165 patients with SLE a subgroup of eight patients with active SLE yet with persistently negative tests for ANF and LE cells was identified. These patients were characterized by a photosensitive skin rash with a negative lupus band test, a high incidence of arthritis, mild form of renal disease, and a positive family history for connective tissue disease. Antibodies to DNA and cytoplasmic antigens were detected in a few.
摘要
在一项对165例系统性红斑狼疮（SLE）患者的前瞻性研究过程中，发现了一个由8例活动性SLE患者组成的亚组，这些患者的抗核因子（ANF）和狼疮细胞检测结果持续为阴性。这些患者的特征为有光敏性皮疹且狼疮带试验阴性、关节炎发病率高、肾病症状较轻以及结缔组织病家族史呈阳性。少数患者检测到抗DNA抗体和抗细胞质抗原抗体。
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